257956-61-9Relevant academic research and scientific papers
Improved procedure for the reductive acetylation of acyclic esters and a new synthesis of ethers
Kopecky, David J.,Rychnovsky, Scott D.
, p. 191 - 198 (2000)
An optimized protocol for the DIBALH reductive acetylation of acyclic esters and diesters is described. This reductive acetylation procedure allows a wide variety of esters to be converted into the corresponding α-acetoxy ethers in good to excellent yields. It was found that, under mild acidic conditions, many α-acetoxy ethers can be further reduced to the corresponding ethers. This net two-step ester deoxygenation is an attractive alternative to the classical Williamson synthesis for certain ethers.
