25800-42-4Relevant articles and documents
Catalase Involved in Oxidative Cyclization of the Tetracyclic Ergoline of Fungal Ergot Alkaloids
Yao, Yongpeng,An, Chunyan,Evans, Declan,Liu, Weiwei,Wang, Wei,Wei, Guangzheng,Ding, Ning,Houk,Gao, Shu-Shan
, p. 17517 - 17521 (2019)
A dedicated enzyme for the formation of the central C ring in the tetracyclic ergoline of clinically important ergot alkaloids has never been found. Herein, we report a dual role catalase (EasC), unexpectedly using O2 as the oxidant, that catalyzes the oxidative cyclization of the central C ring from a 1,3-diene intermediate. Our study showcases how nature evolves the common catalase for enantioselective C-C bond construction of complex polycyclic scaffolds.