2581-36-4Relevant academic research and scientific papers
Methylenedisalicylic acid derivatives: New PTP1B inhibitors that confer resistance to diet-induced obesity
Shrestha, Suja,Bhattarai, Bharat Raj,Chang, Kyung Ja,Lee, Keun-Hyeung,Cho, Hyeongjin
, p. 2760 - 2764 (2008/02/04)
Methylenedisalicylic acid derivatives were synthesized and their inhibitory activities against protein tyrosine phosphatases (PTPases) examined. Two of the compounds, 8 and 9, showed Ki values of 9.4 and 6.3 μM against PTP1B, 4- and 7-fold lower values compared to those against TC-PTP. They were reversible and slow-binding inhibitors against PTP1B. When compound 8 was fed to a mouse model, the weight gain and adipocyte fat storage induced by a high-fat-diet were significantly suppressed.
Synthesis and Anti-HIV Activities of Low Molecular Weight Aurintricarboxylic Acid Fragments and Related Compounds
Cushman, Mark,Kanamathareddy, Suseela,Clerq, Erik de,Schols, Dominique,Goldman, Mark E.,Bowen, Julie A.
, p. 337 - 342 (2007/10/02)
Several compounds corresponding to fragments of the schematic representation of the polymeric structure of aurintricarboxylic acid (ATA) have been prepared and tested for prevention of the cytopathic effect of HIV-1 and HIV-2 in MT-4 cell culture and HIV-
