25814-07-7

Basic information

• Product Name: (4-AMino-3-chloro-phenyl)-acetic acid ethyl ester
• Synonyms: (4-AMino-3-chloro-phenyl)-acetic acid ethyl ester
• CAS NO: 25814-07-7
• Molecular Formula: C₁₀H₁₂ClNO₂
• Molecular Weight: 213.66078
• Mol File: 25814-07-7.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4-AMino-3-chloro-phenyl)-acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (4-AMino-3-chloro-phenyl)-acetic acid ethyl ester(25814-07-7)
• EPA Substance Registry System: (4-AMino-3-chloro-phenyl)-acetic acid ethyl ester(25814-07-7)

Safety Data

• Hazardous Substances Data: 25814-07-7(Hazardous Substances Data)

Usage

Description

(4-Amino-3-chloro-phenyl)-acetic acid ethyl ester is a chemical compound with the molecular formula C10H12ClNO2. It is an ethyl ester derivative of (4-amino-3-chlorophenyl) acetic acid, which is a derivative of phenylacetic acid. (4-AMino-3-chloro-phenyl)-acetic acid ethyl ester is known for its potential applications in the pharmaceutical industry and as a building block for the preparation of other organic compounds.

Uses

Used in Pharmaceutical Industry:
(4-Amino-3-chloro-phenyl)-acetic acid ethyl ester is used as a key intermediate in the synthesis of various drugs. Its unique chemical structure allows it to be a versatile building block for the development of new medications for a wide range of conditions.
Used in Organic Chemistry:
(4-AMino-3-chloro-phenyl)-acetic acid ethyl ester is also used as a starting material for the preparation of other organic compounds. Its reactivity and functional groups make it a valuable component in the synthesis of various chemical products.
Safety Precautions:
It is important to handle and store (4-Amino-3-chloro-phenyl)-acetic acid ethyl ester with caution, following proper safety protocols and regulations to ensure the safety of individuals and the environment.

Upstream product

• 1093222-12-8 ethyl 3-chloro-4-nitrophenylacetate 
• 5438-70-0 ethyl (4-amino-3,5-dibromophenyl)acetate 

Downstream Products

• 1021167-92-9 ethyl {4-[4,9-bis(ethyloxy)-1,3-dioxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl]-3-chlorophenyl}acetate 
• 22106-57-6 (4-amino-3-chlorophenyl)acetic acid 
• 1198420-24-4 ethyl (3-chloro-4-{[(5-chloro-2-{[(2-chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetate 
• 1198420-07-3 ethyl (3-chloro-4-{[(5-chloro-2-{[(3-chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetate 
• 1198420-19-7 ethyl (3-chloro-4-{[(2-{[(3-chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetate 
• 1198420-12-0 ethyl {3-chloro-4-[({5-chloro-2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetate 
• 1198420-17-5 ethyl {3-chloro-4-[({2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetate 
• 1093222-15-1 ethyl 3-chloro-4-[N'-(5-fluoro-2-methylphenyl)ureido]phenylacetate 
• 1093222-13-9 ethyl 3-chloro-4-[N'-(3-fluoro-2-methylphenyl)ureido]phenylacetate 
• 1093222-14-0 ethyl 3-chloro-4-[N'-(4-fluoro-2-methylphenyl)ureido]phenylacetate 
• 1034025-88-1 ethyl (3-chloro-4-{[(2-chloro-5-{[(3-chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetate 
• 441715-73-7 ethyl 3-chloro-4-(1-(6-fluoroindolinyl)carbonylamino)phenylacetate 
• 81265-57-8 (3-Chloro-4-indazol-2-yl-phenyl)-acetic acid 
• 945561-64-8 ethyl (3-chloro-4-{1,3-dioxo-4,9-bis[(phenylmethyl)oxy]-1,3-dihydro-2H-benzo[f]isoindol-2-yl}phenyl)acetate 

Relevant articles and documents

Halogenation of 4-hydroxy/amino-3-methoxyphenyl acetamide TRPV1 agonists showed enhanced antagonism to capsaicin

As an extension of our analysis of the effect of halogenation on thiourea TRPV1 agonists, we have now modified selected 4-hydroxy(or 4-amino)-3- methoxyphenyl acetamide TRPV1 agonists by 5- or 6-halogenation on the aromatic A-region and evaluated them for potency for TRPV1 binding and regulation and for their pattern of agonism/antagonism (efficacy). Halogenation shifted the functional activity at TRPV1 toward antagonism with a greater extent of antagonism as the size of the halogen increased (I > Br > Cl), as previously observed for the thiourea series. The extent of antagonism was greater for halogenation at the 5-position than at the 6-position, in contrast to SAR for the thiourea series. In this series, compounds 55 and 75 showed the most potent antagonism, with Ki (ant) = 2.77 and 2.19 nM, respectively, on rTRPV1 expressed in Chinese hamster ovary cells. The compounds were thus ca. 40-60-fold more potent than 6′-iodononivamide.

NOVEL EP4 RECEPTOR AGONIST COMPOUNDS

A compound selected from the group consisting of: (3-chloro-4-{[(5-chloro-2-{[(2- chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetic acid; {4-[({5-chloro-2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; {3-chloro-4-[({5-chloro-2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; (3-chloro-4-{[(5-chloro-2-{[(3- chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetic acid; {4-[({2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; (4-{[(5-chloro-2-{[(3-chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}-2- fluorophenyl)acetic acid; {3-chloro-4-[({2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; (3-chloro-4-{[(2-{[(3-chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetic acid; {4-[({2-chloro-6-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; (4-{[(2-chloro-6-{[(3-chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetic acid; {4-[({5-chloro-2-[(phenylmethyl)amino]phenyl}carbonyl)amino]phenyl}acetic acid; (4-{[(5-chloro-2-{[(3-chlorophenyl)methyl]amino}phenyl)carbonyl]amino}phenyl)acetic acid; and (4-{[(5-chloro-2-{[(2-chlorophenyl)methyl]amino}phenyl)carbonyl]amino}phenyl)acetic acid, or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.

ISOINDOL DERIVATIVES AS EP4 RECEPTOR AGONISTS

The present invention relates to indole derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medicine.