5438-70-0

Basic information

• Product Name: Ethyl 4-aminophenylacetate
• Synonyms: LABOTEST-BB LT01148116;H-APH(4)-OET;4-AMINOPHENYLACETIC ACID ETHYL ESTER;P-Aminophenyl Acetic Acid Ethyl Ester;Ethyl 4-aminophenylacetate, 98 %;4-Aminobenzeneacetic acid ethyl ester;Ethyl 4-aMinophenylacetate, 98% 1GR;2-(4-aminophenyl)acetic acid ethyl ester
• CAS NO: 5438-70-0
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.22
• EINECS: 202-303-5
• Product Categories: Aromatic Esters;Esters;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het;amine| carboxylic ester
• Mol File: 5438-70-0.mol
• Article Data: 29

Chemical Properties

• Melting Point: 48-50 °C
• Boiling Point: 292.5 °C at 760 mmHg
• Flash Point: 149.4 °C
• Appearance: pinkish-white to beige powder
• Density: 1.112 g/cm³
• Vapor Pressure: 0.000589mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 4.55±0.10(Predicted)
• CAS DataBase Reference: Ethyl 4-aminophenylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 4-aminophenylacetate(5438-70-0)
• EPA Substance Registry System: Ethyl 4-aminophenylacetate(5438-70-0)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• Hazardous Substances Data: 5438-70-0(Hazardous Substances Data)

Usage

Chemical Properties

pinkish-white to beige powder

InChI:InChI=1/C9H11NO2/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6H,2,10H2,1H3

Upstream product

• 5445-26-1 ETHYL 4-NITROPHENYLACETATE 
• 64-17-5 ethanol 
• 1197-55-3 4-aminophenylacetic acid 
• 88975-34-2 ethyl 4-<(trifluoroacetyl)amino>benzeneacetate 
• 5044-24-6 1-(4-Bromo-phenyl)-2,5-dimethyl-1H-pyrrole 
• 26165-63-9 2-<4-(2,5-dimethylpyrrol-1-yl)phenyl>ethanoic acid 
• 13475-17-7 ethyl 2-(4-acetamidophenyl)acetate 
• 140-29-4 phenylacetonitrile 
• 104-03-0 4-nitrobenzeneacetic acid 
• 123-30-8 4-amino-phenol 
• 555-21-5 4-Nitrophenylacetonitrile 
• 105113-62-0 4-<(trifluoroacetyl)amino>benzeneacetic acid 
• 113180-63-5 4-<(trifluoroacetyl)amino>benzeneacetyl chloride 
• 106-40-1 4-bromo-aniline 

Downstream Products

• 22676-74-0 ethyl 2-(4-isothiocyanatophenyl)acetate 
• 68787-97-3 N-methyl-4-ethoxycarbonylmethylaniline 
• 77440-24-5 4-ammino>fenilacetato d'etile 
• 86373-87-7 {4-[3-(4-Chloro-phenyl)-propylamino]-phenyl}-acetic acid ethyl ester 
• 87811-97-0 [4-(2-Benzothiazol-2-yl-2-oxo-ethylamino)-phenyl]-acetic acid ethyl ester 
• 130468-89-2 ethyl 4-<(4-carboxy-1-oxobutyl)amino>benzeneacetate 
• 106506-51-8 (4-{2-[bis-(2-chloro-ethyl)-amino]-2-oxo-2λ⁵-[1,3,2]oxazaphospholidine-4-carbonylamino}-phenyl)-acetic acid ethyl ester 
• 62910-40-1 ethyl 4-(5-chloro-2-methoxybenzamido)-phenylacetate 
• 62910-46-7 ethyl 4-(2-butyloxy-5-chlorobenzamido)-phenylacetate 
• 62910-41-2 ethyl 4-(2-ethoxy-5-chlorobenzamido)-phenylacetate 
• 68195-02-8 2-Amino-6-ethoxycarbonylmethylbenzothiazole 
• 62910-44-5 ethyl 4-(2-pentyloxy-5-chlorobenzamido)-phenylacetate 
• 62910-42-3 ethyl 4-(2-methoxy-5-methylbenzamido)-phenylacetate 
• 68788-00-1 (4-benzenesulfonylamino-phenyl)-acetic acid ethyl ester 

Relevant articles and documents

Chemoselective Hydrogenation of Nitroarenes Using an Air-Stable Base-Metal Catalyst

The reduction of nitroarenes to anilines as well as azobenzenes to hydrazobenzenes using a single base-metal catalyst is reported. The hydrogenation reactions are performed with an air-and moisture-stable manganese catalyst and proceed under relatively mild reaction conditions. The transformation tolerates a broad range of functional groups, affording aniline derivatives and hydrazobenzenes in high yields. Mechanistic studies suggest that the reaction proceeds via a bifunctional activation involving metal-ligand cooperative catalysis.

Benzo imidazo [2, 1-b] thiazole compound and application thereof (by machine translation)

The invention discloses a benzoimidazo [2, 1-b] thiazole compound and application thereof, and belongs to the technical field of medicines. The inhibitory activity of the synthesized benzimidazo [2, 1-b] thiazole analogues on FLTT3 is more than 90%, wherein the compounds (compounds 2 , 4, 6, 8 and 10) are IC of FLTT3-ITD kinase. 50 Lower value, in particular compound 2, IC IC50 The value is only 5.60 nm, and therefore the compound of the present invention may be used as an inhibitor FLTT3, or for preparing a drug capable of modulating or suppressing diseases associated with abnormal cell proliferation by affecting the enzymatic activity of one or more tyrosine kinases and interfering with aberrant cell proliferation, having a wide application prospect. (by machine translation)

Hapten design and monoclonal antibody to fluoroacetamide, a small and highly toxic chemical

Fluoroacetamide (FAM) is a small (77 Da) and highly toxic chemical, formerly used as a rodenticide and potentially as a poison by terrorists. Poisoning with FAM has occurred in humans, but few reliably rapid detection methods and antidotes have been reported. Therefore, producing a specific antibody to FAM is not only critical for the development of a fast diagnostic but also a potential treatment. However, achieving this goal is a great challenge, mainly due to the very low molecular weight of FAM. Here, we design two groups of FAM haptens for the first time, maximally exposing the fluorine or amino groups, with the aid of linear aliphatic or phenyl-contained spacer arms. Interestingly, whereas the hapten with fluorine at the far end of the hapten did not induce an antibody response to FAM, the hapten with an amino group at the far end and phenyl-contained spacer arm triggered a significantly specific antibody response. Finally, a monoclonal antibody (mAb) named 5D11 was successfully obtained with an IC50 value of 97 μg mL?1 and negligible cross-reactivities to the other nine functional and structural analogs.