25818-96-6

Usage

Chemical class

Barbiturate
A class of drugs that act as central nervous system depressants

Common uses

Sedative, anxiety treatment, insomnia treatment
Reduces anxiety and helps with sleeplessness

Mechanism of action

Enhances the activity of GABA
Increases the calming effect of the neurotransmitter gamma-aminobutyric acid in the brain

Route of administration

Oral
Taken by mouth in the form of tablets or solutions

Potential risks

Abuse, dependence, respiratory depression, overdose
Should be used with caution due to sedative properties and associated risks

Upstream product

• 7424-91-1 methyl 3,3-dimethoxypropionate 
• 691-60-1 N-isopropylurea 
• 75-30-9 2-iodo-propane 
• 66-22-8 uracil 

Relevant academic research and scientific papers

Copper-Catalyzed Regioselective Direct C–H Thiolation and Thiocyanation of Uracils

A novel copper-catalyzed direct C–H thiolation and thiocyanation of uracils using disulfides and thiocyanate salts respectively as coupling partners are described. These reactions enable the C–H bond cleavage and C–S bond formation to proceed efficiently under relatively mild conditions, providing useful methods for a preparation of a series of thio-substituted at the C5 position of uracil derivatives. These protocols exhibit several merits including simple experimental procedures, readily accessible substrates and reagents, broad scopes, high yields, and excellent regioselectivity. Preliminary mechanistic studies revealed that a radical pathway is likely to be involved.

Comparative binding study of steroidal adenine with flavin and uracil derivatives

A comparative binding study of a steroidal adenine derivative based on lithocholic acid with N10-benzylisoalloxazine (flavin) and N 1-iso-propyluracil has been described.

An efficient synthesis of pyrimidines from beta-amino alcohols.

[reaction: see text] Pyrimidinones 3 were chemoselectively reduced by using metal-catalyzed hydrogenation and stereoselectively substituted by various nucleophiles. Starting from beta-amino alcohols 1, the overall process allows efficient access to substi

Improved One-Step Procedure for the Preparation of 1-Substituted and 1,3-Disubstituted Uracils and 2-Thiouracils

A convenient one-pot procedure for the synthesis of 1-substituted and 1,3-disubstituted uracils and 2-thiouracils consists of acylation of ureas or thioureas with methyl 3,3-dimethoxypropanoate in the presence of a strong base, and acidic work-up.The yields range from 36 to 99percent.In all cases, only one regioisomer is isolated.