2582-22-1Relevant academic research and scientific papers
Identification of 3 H -naphtho[1,2,3- de ]quinoline-2,7-diones as inhibitors of apoptosis signal-regulating kinase 1 (ASK1)
Volynets, Galyna P.,Chekanov, Maksym O.,Synyugin, Anatoliy R.,Golub, Andriy G.,Kukharenko, Oleksandr P.,Bdzhola, Volodymyr G.,Yarmoluk, Sergiy M.
experimental part, p. 2680 - 2686 (2011/06/27)
Apoptosis signal-regulating kinase 1 (ASK1) has recently emerged as an attractive therapeutic target for the treatment of cardiac and neurodegenerative disorders. The selective inhibitors of ASK1 may become important compounds for the development of clini
Synthesis of novel substituted anthra [1,9-bc]pyridin-6-ones
Berghot,Moawad
, p. 564 - 5568 (2007/10/03)
Anthrapyridone derivative 5a was formed as a result of cyclohydrolysis of 2 which was obtained from the reaction of 1 with malononitrile, anthrapyridone 5e, 5f and 5g were also formed from cyclization reaction of the prepared new derivative 3, 4a and 4b respectively in basic conditions. While anthrapyridone derivative 5b, 5c and 5d were prepared directly from the reaction of 1 with benzylcyanide, phenyl acetaldehyde and diethyl malonate respectively.
