82-45-1Relevant articles and documents
Hydrogenation of 1-nitroanthraquinone to 1-aminoanthraquinone catalyzed by bimetallic cuptx nanoparticles
Yang, Chenchen,Wang, Aili,Yin, Hengbo
, p. 5906 - 5913 (2019)
Bimetallic CuPtx nanoparticles were prepared in ethanol solution by the wet chemical reduction method using Cu(NO3)2 and H2PtCl6 as starting materials, hydrazine hydrate as a reductant, and polyvinyl pyrrolidone as an organic modifier. The average particle sizes of Cu and Pt nanoparticles were 60 nm and 3 nm, respectively. The small-sized Pt nanoparticles were evenly anchored at the surfaces of large-sized Cu nanoparticles, forming Cu@Pt core-shell structured nanocomposites. In the bimetallic CuPtx nanoparticles, electron was transferred from platinum to copper species, which increased the selectivity of 1-aminoanthraquinone by suppressing the high hydrogenation activity of metallic platinum. The CuPt0.1 bimetallic nanoparticles exhibited higher catalytic activity for the hydrogenation of 1-nitroanthraquinone to 1-aminoanthraquinone than both monometallic Cu and Pt nanoparticles. Over the CuPt0.1 catalyst, the selectivity of 1-aminoanthraquinone was 99.3% at the 1-nitroanthraquinone conversion of 98.9%.
Preparation method of 1-aminoanthraquinone
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Paragraph 0010, (2021/07/01)
A preparation method of 1-aminoanthraquinone comprises the following steps: by taking nickel carbonyl loaded by superparamagnetic nanoparticles as a catalyst and 1-nitroanthraquinone as a reaction substrate, adding a solvent, introducing hydrogen, and conducting reacting at 60-80 DEG C and 0.3-0.5 MPa for 2-8 hours; and applying a magnetic field to the reaction product to recover the catalyst, and performing post-treatment to obtain 1-aminoanthraquinone, wherein the mass of the catalyst is 0.003 times that of the 1-nitroanthraquinone, and the mass ratio of the 1-nitroanthraquinone to the solvent is 15:4. The 1-aminoanthraquinone synthesis process is simple and convenient, high in selectivity, environment-friendly, small in equipment investment and suitable for industrial production. The nickel carbonyl loaded by the superparamagnetic nanoparticles has moderate catalytic activity, nitryl can be selectively reduced, excessive reduction of carbonyl is avoided, the yield of the 1-aminoanthraquinone is high, and the catalyst can be collected and reused through an external magnetic field and can be repeatedly used for at least five times.
TARGETED BIFUNCTIONAL DEGRADERS
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, (2021/04/17)
The present invention provides, in one aspect, bifunctional compounds that can be used to promote or enhance degradation of certain circulating proteins. In another aspect, the present invention provides bifunctional compounds that can be used to promote or enhance degradation of certain autoantibodies. In certain embodiments, treatment or management of a disease and/or disorder requires degradation, removal, or reduction in concentration of the circulating protein or the autoantibody in the subject. Thus, in certain embodiments, administration of a compound of the invention to the subject removes or reduces the circulation concentration of the circulating protein or the autoantibody, thus treating, ameliorating, or preventing the disease and/or disorder. In certain embodiments, the circulating protein is TNF.