258262-54-3

Basic information

• Product Name: N-[2-[4-(AMinosulfonyl)phenyl]ethyl]-carbaMic Acid tert-Butyl Ester
• Synonyms: N-[2-[4-(AMinosulfonyl)phenyl]ethyl]-carbaMic Acid tert-Butyl Ester;(4-SulfaMoylphenethyl)carbaMic Acid tert-Butyl Ester;N-[2-[4-(AMinosulfonyl)phenyl]ethyl]-carbaMic Acid 1,1-DiMethylethyl Ester
• CAS NO: 258262-54-3
• Molecular Formula: C₁₃H₂₀N₂O₄S
• Molecular Weight: 300
• Product Categories: Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Sulfur & Selenium Compounds;Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
• Mol File: 258262-54-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Density: 1.220±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 10.16±0.10(Predicted)
• CAS DataBase Reference: N-[2-[4-(AMinosulfonyl)phenyl]ethyl]-carbaMic Acid tert-Butyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-[4-(AMinosulfonyl)phenyl]ethyl]-carbaMic Acid tert-Butyl Ester(258262-54-3)
• EPA Substance Registry System: N-[2-[4-(AMinosulfonyl)phenyl]ethyl]-carbaMic Acid tert-Butyl Ester(258262-54-3)

Safety Data

• Hazardous Substances Data: 258262-54-3(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

N-[2-[4-(Aminosulfonyl)phenyl]ethyl]carbamic Acid tert-Butyl Ester is used in the preparation of diazepane compounds as chymase inhibitors for treatement of bronchial asthma and urticaria.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 35303-76-5 4-(2-aminoethyl)benzenesulfonamide 

Downstream Products

• 29094-61-9 glipizide 
• 2015-16-9 N-(4-[2-amino-ethyl]-benzenesulfonyl)-N'-cyclohexyl urea 
• 33288-71-0 N-[2-[4-(amino-sulfonyl)phenyl]ethyl]-5-methylpyrazinecarboxamide 

Relevant articles and documents

Synthesis and evaluation of α-glucosidase inhibitory activity of sulfonylurea derivatives

Two series of sulfonylureas derivatives including 24 compounds (4, 7, 5a-5o, 8a-8h), among them 17 new derivatives, have been synthesized and evaluated for their α-glucosidase inhibitory activity. Compounds 5c, 5h and 8e showed significant in vitro α-glucosidase inhibition with IC50 values of 5.58, 79.85 and 213.36 μm, respectively, comparing with the standard compounds acarbose (IC50 = 268.29 μm) and glipizide (IC50 = 300.47 μm). The preliminary structure-activity relationships (SARs) of the synthesized compounds were also investigated.

Styrene sulfone NLRP3 inflammasome inhibitor, preparation method and application thereof

The invention relates to the field of styrene sulfone compounds and NLRP3 inhibitors, and particularly provides a styrene sulfone NLRP3 inflammasome inhibitor, a preparation method and application thereof, wherein the inhibitor is represented by a formula (1), n is selected from 0 and 1, X is selected from N and O, R1 is selected from different electron withdrawing or electron donating substituents, and R2 is selected from different fat or aromatic substituents. According to the invention, it is verified that the compounds represented by the general formula have NLRP3 inhibitory activity.

NOVEL COMPOUNDS AND USES

The present invention relates to compounds of formula (I): wherein Q is O or S; R1 is a cyclic group substituted with at least one group X, wherein R1 may optionally be further substituted; X is any group comprising a carbonyl group; and R2 is a cyclic group substituted at the α-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the dual action of NLRP3 inhibition and the stimulation of insulin secretion.