2015-16-9

Basic information

• Product Name: Des(5-Methylpyrazinecarbonyl) Glipizide
• Synonyms: Des(5-Methylpyrazinecarbonyl) Glipizide;1-[[p-(2-AMinoethyl)phenyl]sulfonyl]-3-cyclohexylurea;4-(2-AMinoethyl)-N-[(cyclohexylaMino)carbonyl]benzenesulfonaMide;Potassium Clavulanate Impurity 6;4-(2-aminoethyl)-N-(cyclohexylcarbamoyl)benzenesulfonamide(WXG01430)
• CAS NO: 2015-16-9
• Molecular Formula: C₁₅H₂₃N₃O₃S
• Molecular Weight: 325.42642
• Product Categories: Amines;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Amines, Heterocycles, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
• Mol File: 2015-16-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 183-185 °C
• Appearance: /
• Density: 1.27±0.1 g/cm3(Predicted)
• PKA: 4.77±0.10(Predicted)
• CAS DataBase Reference: Des(5-Methylpyrazinecarbonyl) Glipizide(CAS DataBase Reference)
• NIST Chemistry Reference: Des(5-Methylpyrazinecarbonyl) Glipizide(2015-16-9)
• EPA Substance Registry System: Des(5-Methylpyrazinecarbonyl) Glipizide(2015-16-9)

Safety Data

• Hazardous Substances Data: 2015-16-9(Hazardous Substances Data)

Usage

Uses

Glipizide (G410225) impurity. A degradation product of Glipizide and glyburide (G598350).

Upstream product

• 258262-54-3 tert-butyl (4-sulfamoyl phenethyl)carbamate 
• 35303-76-5 4-(2-aminoethyl)benzenesulfonamide 
• 3173-53-3 Cyclohexyl isocyanate 
• 41472-49-5 4-(β-acetylaminoethyl)phenylsulfonamide 
• 2191-62-0 C₁₇H₂₅N₃O₄S 

Downstream Products

• 158435-38-2 N-<4-(2-<4-azido-2-hydroxybenzamido>ethyl)benzenesulfonyl>-N'-cyclohexylurea 
• 88759-61-9 C₂₅H₃₂N₄O₆S 
• 29094-61-9 glipizide 
• 33288-71-0 N-[2-[4-(amino-sulfonyl)phenyl]ethyl]-5-methylpyrazinecarboxamide 
• 10311-83-8 2-((4-[N-(cyclohexylcarbamoyl)sulfamoyl]phenethyl)carbamoyl)benzoic acid 
• 30961-30-9 N-{4-[N-(cyclohexylcarbamoyl)sulfamoyl]phenethyl}quinoxaline-2-carboxamide 
• 2037-67-4 N-{4-[N-(cyclohexylcarbamoyl)sulfamoyl]phenethyl}-4-methoxybenzamide 
• 25210-69-9 N-{4-[N-(cyclohexylcarbamoyl)sulfamoyl]phenethyl}cinnamamide 
• 2037-72-1 UR 603 

Relevant articles and documents

Synthesis and evaluation of α-glucosidase inhibitory activity of sulfonylurea derivatives

Two series of sulfonylureas derivatives including 24 compounds (4, 7, 5a-5o, 8a-8h), among them 17 new derivatives, have been synthesized and evaluated for their α-glucosidase inhibitory activity. Compounds 5c, 5h and 8e showed significant in vitro α-glucosidase inhibition with IC50 values of 5.58, 79.85 and 213.36 μm, respectively, comparing with the standard compounds acarbose (IC50 = 268.29 μm) and glipizide (IC50 = 300.47 μm). The preliminary structure-activity relationships (SARs) of the synthesized compounds were also investigated.

Styrene sulfone NLRP3 inflammasome inhibitor, preparation method and application thereof

The invention relates to the field of styrene sulfone compounds and NLRP3 inhibitors, and particularly provides a styrene sulfone NLRP3 inflammasome inhibitor, a preparation method and application thereof, wherein the inhibitor is represented by a formula (1), n is selected from 0 and 1, X is selected from N and O, R1 is selected from different electron withdrawing or electron donating substituents, and R2 is selected from different fat or aromatic substituents. According to the invention, it is verified that the compounds represented by the general formula have NLRP3 inhibitory activity.

Hypoglycemic compounds. Amino acid derivatives of sulfonylurea. II

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