258265-78-0

Upstream product

• 920520-69-0 (2R)-3-benzyloxy-2-methylpropyl methanesulfonate 
• 143-33-9 sodium cyanide 
• 63930-46-1 (S)-3-benzyloxy-2-methylpropan-1-ol 

Downstream Products

• 945001-90-1 (S)-4-(benzyloxy)-3-methylbutanimidamide 
• 90865-69-3 (3S)-4-Benzyloxy-3-methyl-butyraldehyde 

Relevant academic research and scientific papers

Synthetic studies toward amphidinolide H1: Segment C14-C26

Stereoselective synthesis of the C14-C26 moiety of amphidinolide H1 is described. The key features of the approach include the convergent fragment assembly with a highly diastereoselective aldol reaction to establish the C18 stereochemistry and using comm

INHIBITORS OF TNFα, PDE4 AND B-RAF, COMPOSITIONS THEREOF AND METHODS OF USE THEREWITH

Provided herein are compounds having TNFα and/or PDE4 and/or B-RAF inhibitory activity, and compositions thereof. In particular, provided herein are compounds of the formula (I) and pharmaceutically acceptable salts, solvates, hydrates, clathrates, stereoisomers, polymorphs and prodrugs thereof, wherein Ar, R1, R2, R3, R4, n and Z are as described herein. Further provided herein are methods for treating or preventing various diseases and disorders by administering to a patient one or more TNFα and/or PDE4 and/or B-RAF inhibitors. In particular, provided herein are methods for preventing or treating cancer, inflammatory disorders, cognition and memory disorders and autoimmune disorders, or one or more symptoms thereof by administering to a patient one or more TNFα and/or PDE4 and/or B-RAF inhibitors.