258277-02-0Relevant academic research and scientific papers
Pyrrolo[2,1-c][1,2,4]triazines from 2-diazopyrroles: Synthesis and antiproliferative activity
Diana, Patrizia,Barraja, Paola,Lauria, Antonino,Montalbano, Alessandra,Almerico, Anna Maria,Dattolo, Gaetano,Cirrincione, Girolamo
, p. 267 - 272 (2007/10/03)
Pyrrolo[2,1-c][1,2,4]triazines 4a-g were directly obtained from the reaction of 2-diazopyrroles 1a and b with the sodium salts of β-diketones, β-carbonitriles, and β-dinitriles. Only when the 2-diazopyrroles were coupled with ethyl cyanoacetate, it was possible to isolate, together with the pyrrolotriazines, the intermediate hydrazones 3 which, in turn, cyclised to the title ring system. Pyrrolotriazines 4a-e were evaluated for cytotoxic activity against a panel of 60 human cancer cell lines by the National Cancer Institute and some of them demonstrated inhibitory effects in the growth of a wide range of cancer cell lines generally at 10-5 M level and in some cases at micromolar concentrations.
Pyrrolo[2,1-d][1,2,3,5]tetrazines, a new class of azolotetrazines related to the antitumor drug temozolomide
Diana, Patrizia,Barraja, Paola,Lauria, Antonino,Almerico, Anna Maria,Dattolo, Gactano,Cirrincione, Girolamo
, p. 2082 - 2086 (2007/10/03)
A series of derivatives of the new ring system pyrrolo[2,1- d][1,2,3,5]tetrazine, potential antineoplastic agents, were obtained in good yield from the reaction of 2-diazopyrroles with isocyanates at room temperature and in the dark. Atomic charges at C-4
