462662-57-3Relevant academic research and scientific papers
Pyrrolo[2,1-c][1,2,4]triazines from 2-diazopyrroles: Synthesis and antiproliferative activity
Diana, Patrizia,Barraja, Paola,Lauria, Antonino,Montalbano, Alessandra,Almerico, Anna Maria,Dattolo, Gaetano,Cirrincione, Girolamo
, p. 267 - 272 (2002)
Pyrrolo[2,1-c][1,2,4]triazines 4a-g were directly obtained from the reaction of 2-diazopyrroles 1a and b with the sodium salts of β-diketones, β-carbonitriles, and β-dinitriles. Only when the 2-diazopyrroles were coupled with ethyl cyanoacetate, it was possible to isolate, together with the pyrrolotriazines, the intermediate hydrazones 3 which, in turn, cyclised to the title ring system. Pyrrolotriazines 4a-e were evaluated for cytotoxic activity against a panel of 60 human cancer cell lines by the National Cancer Institute and some of them demonstrated inhibitory effects in the growth of a wide range of cancer cell lines generally at 10-5 M level and in some cases at micromolar concentrations.
