25828-29-9

Upstream product

• 124313-67-3 dimethyl 5-phenyl-1-tetrazolyloxy-1,2-ethylenedicarboxylate 
• 131183-01-2 5-phenyl-2-((trimethylsilyl)methyl)-2H-tetrazole 
• 616-38-6 carbonic acid dimethyl ester 
• 100-47-0 benzonitrile 
• 1856-33-3 5-benzhydryl-1H-1,2,3,4-tetrazole 

Downstream Products

• 493003-26-2 N'-(2-(5-phenyl-2H-tetrazol-2-yl)acetyl)furan-2-carbohydrazide 
• 1630042-23-7 2-oxo-N'-(2-(5-phenyl-2H-tetrazol-2-yl)acetyl)-2H-chromene-3-carbohydrazide 
• 1630042-24-8 (E)-3-(4-methoxyphenyl)-N'-(2-(5-phenyl-2H-tetrazol-2-yl)acetyl)acrylohydrazide 
• 1630042-25-9 N'-(2-(5-phenyl-2H-tetrazol-2-yl)acetyl)pivalohydrazide 
• 67037-01-8 2-(5-phenyl-2H-tetrazole-2-yl)acetohydrazide 
• 127221-40-3 4-nitro-N'-(2-(5-phenyl-2H-tetrazol-2-yl)acetyl)benzohydrazide 
• 127221-42-5 2-chloro-N'-(2-(5-phenyl-2H-tetrazol-2-yl)acetyl)benzohydrazide 
• 1630042-19-1 2-bromo-N'-(2-(5-phenyl-2H-tetrazol-2-yl)acetyl)benzohydrazide 
• 1630042-20-4 2-chloro-5-nitro-N'-(2-(5-phenyl-2H-tetrazol-2-yl)acetyl)benzohydrazide 
• 1630042-21-5 3,5-dimethoxy-N'-(2-(5-phenyl-2H-tetrazol-2-yl)acetyl)benzohydrazide 

Relevant academic research and scientific papers

Reactions of 2-[lithio(trimethylsilyl)methyl]-2 H -tetrazoles: Synthesis of 2-[1-(trimethylsilyl)alkyl]-2 H -tetrazoles and (2 H -tetrazol-2-yl)acetates

The reaction of 2-[(trimethylsilyl)methyl]-2H-tetrazoles with various alkyl halides and carbonates using n-butyllithium or lithium diisopropylamide (LDA) gave 2-[1-(trimethylsilyl)alkyl]-2H-tetrazoles and (2H-tetrazol-2-yl)acetates as useful synthons of m

Novel ((phenyltetrazolyl)methyl)oxadiazole derivatives and use thereof

The present invention relates to a compound represented by chemical formula I or a pharmaceutically acceptable salt thereof, and to a pharmaceutical composition and a functional health food comprising the compound or the pharmaceutically acceptable salt thereof as an active component for preventing or treating bone diseases. More particularly, the composition of the present invention has an effect of suppressing differentiation and activation of osteoclasts and can suppress bone diseases caused by bone loss, thereby being useful as a pharmaceutical composition for preventing or treating the diseases.COPYRIGHT KIPO 2016

Synthesis, characterization, and biological evaluation of oxadiazole derivatives bearing 5-phenyl-tetrazole as osteoclast differentiation inhibitors

Novel oxadiazoles bearing 5-phenyl-tetrazole (5a-k) were designed and efficiently synthesized by treating 2-(5-phenyl-2H-tetrazole-2-yl)acetohydrazide (4) with aromatic carboxylic acids in POCl3, and their in vitro anti-osteoclastogenic activities were evaluated. In the cell-based osteoclast differentiation model, all compounds (5a-k) inhibited the formation of osteoclasts. In addition, the potential target molecules of compound 5 analogs were predicted with their chemical substructures via a web-based interface, and some of them were found to be related to osteoclast differentiation. Consequently, the scaffold containing oxadiazole-tetrazole in a single molecule and their analogs are of potential use in the design of novel anti-osteoclastogenic therapeutics.

Novel N-acyl/aroyl-2-(5-phenyl-2H-tetrazol-2-yl)acetohydrazides: Synthesis and characterization

A number of novel N -acyl/aroyl-2-(5-phenyl-2H-tetrazol-2-yl) acetohydrazides (4a-j) of biological interest were efficiently synthesized by treating 2-(5-phenyl-2H-tetrazole-2-yl)acetohydrazide (3) with a variety of aroyl/heterocyclyl or alkanoyl chlorides. FTIR, 1H NMR, 13C NMR, GC-MS, and elemental analyses data confirmed the structures assigned to the newly synthesized compounds. TUeBITAK.

THE MICHAEL TYPE ADDITIONS OF TETRAZOLE DERIVATIVES TO DOUBLE AND TRIPLE CARBON-CARBON BONDS

The reactions of 5-substituted tetrazoles, 1-substituted tetrazolin-5-ones and 5-substituted 1-hydroxytetrazoles with ethylene derivatives possessing electron withdrawing substituents were found to be of practical value in preparing variously substituted