67037-01-8

Usage

Uses

Used in Pharmaceutical Industry:
(5-PHENYL-TETRAZOL-2-YL)-ACETIC ACID HYDRAZIDE is used as a building block for the synthesis of various pharmaceuticals due to its potential bioactivity and reactivity with other functional groups. Its tetrazole ring and hydrazide group contribute to the development of new drugs with improved properties and therapeutic effects.
Used in Agrochemical Industry:
(5-PHENYL-TETRAZOL-2-YL)-ACETIC ACID HYDRAZIDE is used as a key intermediate in the synthesis of agrochemicals, particularly in the development of new pesticides and other agricultural chemicals. Its versatility and reactivity allow for the creation of novel compounds with enhanced efficacy and selectivity in controlling pests and diseases in the agricultural sector.
Used in Organic Synthesis:
(5-PHENYL-TETRAZOL-2-YL)-ACETIC ACID HYDRAZIDE is used as a valuable intermediate for the synthesis of diverse organic compounds. Its reactivity with other functional groups enables the development of new molecules with various applications, such as in the fields of materials science, chemical research, and specialty chemicals.

InChI:InChI=1/C9H10N6O/c10-11-8(16)6-15-13-9(12-14-15)7-4-2-1-3-5-7/h1-5H,6,10H2,(H,11,16)

Upstream product

• 21054-65-9 5-phenyl-2-tetrazolylacetic acid ethyl ester 
• 21743-68-0 5-phenyl-2H-tetrazolylacetic acid 
• 100-47-0 benzonitrile 
• 25828-29-9 (5-phenyltetrazol-2-yl)acetic acid methyl ester 
• 18039-42-4 5-phenyl-2H-1,2,3,4-tetrazole 
• 165816-78-4 2-(5-phenyl-2H-tetrazol-2-yl)acetic acid chloride 

Downstream Products

• 76507-14-7 1-(5-phenyl-2H-tetrazol-2-ylacetyl)-4-(3,4-dimethylphenyl)thiosemicarbazide 
• 76507-12-5 C₁₆H₁₄IN₇OS 
• 76507-13-6 C₁₈H₁₉N₇OS 
• 76507-06-7 1-(5-phenyl-2H-tetrazol-2-ylacetyl)-4-(4-tolyl)thiosemicarbazide 
• 76507-04-5 1-(5-phenyl-2H-tetrazol-2-ylacetyl)-4-(2-tolyl)thiosemicarbazide 
• 76507-05-6 1-(5-phenyl-2H-tetrazol-2-ylacetyl)-4-(3-tolyl)thiosemicarbazide 
• 127221-40-3 4-nitro-N'-(2-(5-phenyl-2H-tetrazol-2-yl)acetyl)benzohydrazide 
• 127221-42-5 2-chloro-N'-(2-(5-phenyl-2H-tetrazol-2-yl)acetyl)benzohydrazide 
• 1630042-19-1 2-bromo-N'-(2-(5-phenyl-2H-tetrazol-2-yl)acetyl)benzohydrazide 
• 1630042-20-4 2-chloro-5-nitro-N'-(2-(5-phenyl-2H-tetrazol-2-yl)acetyl)benzohydrazide 
• 1630042-21-5 3,5-dimethoxy-N'-(2-(5-phenyl-2H-tetrazol-2-yl)acetyl)benzohydrazide 
• 1630042-22-6 4-bromo-3,5-dimethoxy-N'-(2-(5-phenyl-2H-tetrazol-2-yl)acetyl)benzohydrazide 
• 493003-26-2 N'-(2-(5-phenyl-2H-tetrazol-2-yl)acetyl)furan-2-carbohydrazide 
• 1630042-23-7 2-oxo-N'-(2-(5-phenyl-2H-tetrazol-2-yl)acetyl)-2H-chromene-3-carbohydrazide 

Relevant academic research and scientific papers

Novel ((phenyltetrazolyl)methyl)oxadiazole derivatives and use thereof

The present invention relates to a compound represented by chemical formula I or a pharmaceutically acceptable salt thereof, and to a pharmaceutical composition and a functional health food comprising the compound or the pharmaceutically acceptable salt thereof as an active component for preventing or treating bone diseases. More particularly, the composition of the present invention has an effect of suppressing differentiation and activation of osteoclasts and can suppress bone diseases caused by bone loss, thereby being useful as a pharmaceutical composition for preventing or treating the diseases.COPYRIGHT KIPO 2016

Synthesis, characterization, and biological evaluation of oxadiazole derivatives bearing 5-phenyl-tetrazole as osteoclast differentiation inhibitors

Novel oxadiazoles bearing 5-phenyl-tetrazole (5a-k) were designed and efficiently synthesized by treating 2-(5-phenyl-2H-tetrazole-2-yl)acetohydrazide (4) with aromatic carboxylic acids in POCl3, and their in vitro anti-osteoclastogenic activities were evaluated. In the cell-based osteoclast differentiation model, all compounds (5a-k) inhibited the formation of osteoclasts. In addition, the potential target molecules of compound 5 analogs were predicted with their chemical substructures via a web-based interface, and some of them were found to be related to osteoclast differentiation. Consequently, the scaffold containing oxadiazole-tetrazole in a single molecule and their analogs are of potential use in the design of novel anti-osteoclastogenic therapeutics.

Novel N-acyl/aroyl-2-(5-phenyl-2H-tetrazol-2-yl)acetohydrazides: Synthesis and characterization

A number of novel N -acyl/aroyl-2-(5-phenyl-2H-tetrazol-2-yl) acetohydrazides (4a-j) of biological interest were efficiently synthesized by treating 2-(5-phenyl-2H-tetrazole-2-yl)acetohydrazide (3) with a variety of aroyl/heterocyclyl or alkanoyl chlorides. FTIR, 1H NMR, 13C NMR, GC-MS, and elemental analyses data confirmed the structures assigned to the newly synthesized compounds. TUeBITAK.

Acylation of amines with 5-phenyltetrazol-2-ylacetyl chloride

The acylation of primary and secondary amines by 5-phenyltetrazol-2- ylacetyl chloride leads to the corresponding tetrazolylacetamides irrespective of the nature of the substituent in the structure of the amine.

Aminolysis of 5-phenyl-2-tetrazolylacetic acid ethyl ester

It was shown using 5-phenyl-2-tetrazolylacetic acid ethyl ester as an example that aminolysis is a competitive method of synthesizing primary amides. The efficiency of aminolysis by primary amines is linked to the basicity of the initial amine. Highly bas

Carbon-13 Nuclear Magnetic Resonance Spectra of Substituted-s-triazolyl Tetrazoles

The natural abundance carbon-13 nuclear magnetic resonance spectra of various 5-aryltetrazoles, 1-(5-aryltetrazol-2-ylacetyl)-4-phenyl thiosemicarbazides and 5-(5-aryltetrazol-2-ylmethyl)-4-phenyl-s-triazole-3-thiols were recorded using Fourier transform