25834-38-2Relevant academic research and scientific papers
Cobalt-catalyzed directed alkylation of olefinic C-H bond with primary and secondary alkyl chlorides
Yamakawa, Takeshi,Seto, Yuan Wah,Yoshikai, Naohiko
, p. 340 - 344 (2015)
A cobalt-N-heterocyclic carbene catalytic system promotes pyridine-directed olefinic C-H alkylation reactions using a variety of primary and secondary alkyl chlorides under mild conditions. Radical clock experiments suggest that the reaction involves single-electron transfer from the cobalt intermediate to the alkyl chloride.
Synthesis of steroidal and nonsteroidal vicinal heterocyclic alcohols, N-(1-cycloalkenyl)heterocycles and their antibacterial studies
Saikia, Pallabi,Kaishap, Partha Pratim,Goswami, Jonalee,Singh, Anil Kumar,Deka Boruah, Hari Prasanna,Gogoi, Sanjib,Boruah, Romesh C.
, p. 36 - 45 (2014)
A solvent free steroidal and nonsteroidal epoxide ring opening reaction by nitrogen containing heterocycles under microwave irradiation is described. Some of the epoxide ring opening compounds were converted to their corresponding N-(1-cycloalkenyl)heterocycles via an acid catalyzed dehydration reaction. The antimicrobial activities of the epoxide ring opening compounds and N-(1-cycloalkenyl)heterocyclic compounds were tested by agar diffusion assay. Compounds 6, 9-12, 24 and 27 showed moderate inhibition against the growth of pathogenic bacteria Escherichia coli, Pseudomonas syringae, Bacillus subtilis, Proteus vulgaris and Staphylococcus aureus.
Synthesis of N-cycloalkenylazoles.
Katritzky, Alan R,Maimait, Rexiat,Xu, Yong-Jiang,Gyoung, Young Soo
, p. 8230 - 8233 (2002)
N-(1-Cycloalkenyl)pyrroles 3a,b, -pyrazoles 6a,b, and -imidazoles 9a,b were synthesized via elimination of benzotriazole or 5-phenyltetrazole from the corresponding 1-[1-(heterocycyl)cycloalkyl]benzotriazoles 2, 5, and 8 or 1-[1-(heterocycyl)cyclohexyl]-5-phenyltetrazole (12 and 14). Intermediates 2, 5, 8, 12 and 14 were obtained by cyclizations of dihaloalkanes with N-(benzotriazol-1-ylmethyl)heterocycles, 1-imidazol-1-ylmethyl-5-phenyltetrazole (11), or 1-pyrazol-1-ylmethyl-5-phenyltetrazole (13) in the presence of n-BuLi.
Rh-Catalyzed Direct Carboxylation of Alkenyl C?H Bonds of Alkenylpyrazoles
Saitou, Takanobu,Jin, Yushu,Isobe, Kotaro,Suga, Takuya,Takaya, Jun,Iwasawa, Nobuharu
supporting information, p. 1941 - 1944 (2020/06/10)
The Rh-catalyzed direct carboxylation of alkenyl C?H bonds was achieved by using pyrazole as a removable directing group. In the presence of 5 mol% RhCl3 ? 3H2O, 6 mol% P(Mes)3, and 2 equiv. of AlMe2(OMe), the alkenyl C?H bond of various alkenylpyrazoles was directly carboxylated in good yields under CO2 atmosphere. Furthermore, several useful transformations of the pyrazole moiety of the product were achieved to afford synthetically useful carboxylic acid derivatives in good yields.
