258500-82-2

Upstream product

• 258500-75-3 2-(4-iodophenyl)-2-(2,2-dimethoxyethyl)-4,4-dimethoxybutyronitrile 
• 16004-15-2 1-bromomethyl-4-iodobenzene 
• 593-51-1 methylamine hydrochloride 
• 74-89-5 methylamine 

Downstream Products

• 1256340-73-4 C₁₃H₁₆INO₂*ClH 
• 473735-59-0 4-(4-iodo-phenyl)-1-methyl-piperidine-4-carboxylic acid pyridine salt 

Relevant academic research and scientific papers

Synthesis and biological evaluation of meperidine analogues at monoamine transporters

A series of aryl-substituted meperidine analogues was synthesized, and the binding affinities were determined at the DAT, SERT, and NET as well as at μ-opioid receptors. Generally the analogues exhibited increased affinity for the DAT and SERT relative to

Aryl and biaryl piperidines with MCH modulatory activity

In one embodiment, this invention provides a novel class of compounds as antagonists of the MCH receptor, methods of preparing such compounds, pharmaceutical compositions containing one or more of the compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention or amelioration or one or more of diseases associated with the MCH receptor. An illustrative inventive compound is shown below: 1

Synthesis, dopamine and serotonin transporter binding affinities of novel analogues of meperidine

A series of meperidine analogues was synthesized and the binding affinities for the dopamine and serotonin transporters were determined. The substituents on the phenyl ring greatly influenced the potency and selectivity of these compounds for the transpor