258523-72-7Relevant academic research and scientific papers
Acyclic phenylalkanediols as substrates for the study of enzyme recognition: Synthesis of substrates and enzymatic resolution via hydrolysis and transesterification
Rumbero, Angel,Borreguero, Isabel,Sinisterra, Jose V.,Alcantara, Andres R.
, p. 14947 - 14960 (2007/10/03)
Different racemic or prochiral phenyl alkane (1,n)-diols were synthesized, and their resolution was carried out by two different strategies: enzymatic transesterification with vinyl acetate, or enzymatic hydrolysis of their corresponding diacetates, in both cases catalysed by porcine pancreatic lipase (PPL). The absolute configuration of the optically enriched reaction products was determined by formation of Mosher's esters or by the use of the Benzene Sector and Benzene Chirality Rules as obtained from the Circular Dichroism spectra.
