258831-35-5Relevant articles and documents
Discovery of pyrrole-indoline-2-ones as aurora kinase inhibitors with a different inhibition profile
Chiang, Chao-Cheng,Lin, Yu-Hsiang,Lin, Shu Fu,Lai, Chun-Liang,Liu, Chiawei,Wei, Win-Yin,Yang, Sheng-Chuan,Wang, Ru-Wen,Teng, Li-Wei,Chuang, Shih-Hsien,Chang, Jia-Ming,Yuan, Ta-Tung,Lee, Ying-Shuen,Chen, Paonien,Chi, Wei-Kuang,Yang, Ju-Ying,Huang, Hung-Jyun,Liao, Chu-Bin,Huang, Jiann-Jyh
experimental part, p. 5929 - 5941 (2010/11/04)
A series of pyrrole-indolin-2-ones were synthesized, and their inhibition profile for Aurora kinases was studied. The potent compound 33 with phenylsulfonamido at the C-5 position and a carboxyethyl group at the C-3′ position selectively inhibited Aurora
Sulfonamide substituted indolinones as inhibitors of DNA dependent protein kinase (DNA-PK)
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Page 15, (2010/02/10)
The present invention relates generally to the field of radiosensitizing agents which are capable of enhancing radiotherapy by inhibiting DNA-PK (DNA-protein kinase). In particular, it relates to sulfonamide substituted indolinones which inhibit DNA-PK.
