258848-53-2

Upstream product

• 1080-41-7 diethyl (2-oxocyclohexyl)phosphonate 
• 4392-24-9 Cinnamyl bromide 
• 4392-24-9 3-bromo-1-phenyl-1-propenyl bromide 

Downstream Products

• 76524-81-7 2-Methyl-6-((E)-3-phenyl-allyl)-cyclohexanone 
• 84624-35-1 2-[(E)-3-phenyl-2-propenyl]cyclohexanone 

Relevant academic research and scientific papers

Dephosphorylation of α-fully substituted β-keto phosphonates with LiAlH4; regioselective alkylation of ketones employing phosphonate as a temporary activating group

Alkylation of β-keto phosphonates is performed by treatment of β-keto phosphonates with n-BuLi, followed by addition of alkyl halides. The acquired α-fully substituted β-keto phosphonates are dephosphonylated by treatment of the lithium enolates with LiAlH4, followed by quenching with aqueous H2SO4 solution. This whole procedure represents a new route to regioselective alkylation of ketones.