84624-35-1Relevant articles and documents
Palladium(0)-Catalyzed Reactions of Allylic Benzotriazoles with Enamines: A Novel Method for the Stereoselective Synthesis of (4E)-γ,δ-Unsaturated Ketones
Katritzky, Alan R.,Huang, Zhizhen,Fang, Yunfeng
, p. 7625 - 7627 (1999)
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Cooperative Palladium/Proline-Catalyzed Direct α-Allylic Alkylation of Ketones with Alkynes
Yang, Chi,Zhang, Kaifan,Wu, Zijun,Yao, Hequan,Lin, Aijun
supporting information, p. 5332 - 5335 (2016/11/02)
The cooperative palladium/l-proline-catalyzed direct α-allylic alkylation of ketones with alkynes is achieved. This reaction exhibits high atom economy since a leaving group is not liberated and a stoichiometric amount of extra oxidant is not needed. A br
Palladium-catalyzed allylic alkylation of simple ketones with allylic alcohols and its mechanistic study
Huo, Xiaohong,Yang, Guoqiang,Liu, Delong,Liu, Yangang,Gridnev, Ilya D.,Zhang, Wanbin
supporting information, p. 6776 - 6780 (2014/07/08)
Allylic alcohols were directly used in Pd-catalyzed allylic alkylations of simple ketones under mild reaction conditions. The reaction proceeded smoothly at 20°C by the concerted action of a Pd catalyst, a pyrrolidine co-catalyst, and a hydrogen-bonding solvent, and does not require any additional reagents. A computational study suggested that methanol plays a crucial role in the formation of the π-allylpalladium complex by lowering the activation barrier. Concerted action: Allylic alcohols were directly used in the title reaction under mild conditions. The reaction smoothly proceeds by the concerted action of a Pd catalyst, a pyrrolidine co-catalyst, and a hydrogen-bonding solvent, and does not require any additional reagents. A computational study suggested that methanol plays a crucial role in the formation of the π-allylpalladium complex by lowering the activation barrier.
