258850-06-5Relevant articles and documents
Synthesis and anti-HIV activity of 1,3,4,5-tetrahydro-2H-1,4- benzodiazepin-2-one (TBO) derivatives. Truncated 4,5,6,7-tetrahydro-5- methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-ones (TIBO) analogues
Breslin, Henry J.,Kukla, Michael J.,Kromis, Teresa,Cullis, Heather,De Knaep, Fons,Pauwels, Rudi,Andries, Koen,De Clercq, Erik,Janssen, Marcel A.C.,Janssen, Paul A.J.
, p. 2427 - 2436 (2007/10/03)
4,5,6,7-Tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)- ones (TIBO), 1, have been shown to significantly inhibit HIV-1 replication, as reported in detail in our prior publications. Since our earlier reports, we have modified the TIBO structu