15028-40-7

Basic information

• Product Name: methyl 2-amino-2-phenylacetate hydrochloride
• Synonyms: methyl 2-amino-2-phenylacetate hydrochloride;Benzeneacetic acid, a-amino-, methyl ester, hydrochloride;Methyl a-Phenylglycinate Hydrochloride;H-DL-Phg-Ome.HCl
• CAS NO: 15028-40-7
• Molecular Formula: C₉H₁₂NO₂*Cl
• Molecular Weight: 201.65008
• Mol File: 15028-40-7.mol
• Article Data: 29

Chemical Properties

• Melting Point: 202 °C
• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: methyl 2-amino-2-phenylacetate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-amino-2-phenylacetate hydrochloride(15028-40-7)
• EPA Substance Registry System: methyl 2-amino-2-phenylacetate hydrochloride(15028-40-7)

Safety Data

• Hazardous Substances Data: 15028-40-7(Hazardous Substances Data)

Usage

Uses

Phenylglycine Methyl Ester Hydrochloride, is a substituted Glycine derivative, used as an intermediate for the synthesis of various pharmaceutical compounds. It is also a compound involved in the enzymic synthesis of D-(-)-α-Aminobenzyl penicillin by Penicillin Acylase.

Upstream product

• 780-25-6 N-benzylidene benzylamine 
• 616-38-6 carbonic acid dimethyl ester 
• 100-46-9 benzylamine 
• 100-52-7 benzaldehyde 
• 62506-88-1 N-benzylidenediphenylmethanamine 
• 7699-79-8 benzhydrylidene-benzyl-amine 
• 75-36-5 acetyl chloride 
• 2835-06-5 phenylglycin 
• 75-77-4 chloro-trimethyl-silane 
• 591-51-5 phenyllithium 
• 171181-53-6 methyl N^α-(diphenylmethylene)-DL-phenylglycinate 
• 67-56-1 methanol 
• 21210-43-5 (S)-Methyl mandelate 

Downstream Products

• 3381-63-3 N-Triphenylmethyl-α-amino-phenylessigsaeure-methylester 
• 1603-79-8 phenylglyoxylic acid ethyl ester 
• 93-89-0 benzoic acid ethyl ester 
• 118133-82-7 methyl o-hydroxybenzylidene phenylglycinate 
• 85235-40-1 Methoxycarbonylamino-phenyl-acetic acid methyl ester 
• 83529-46-8 {[1-(3-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-phenyl-acetic acid methyl ester 
• 93782-07-1 α-amino-2-phenyl-N-methylacetamide 
• 58298-90-1 N-formyl-D,L-phenylalanine methyl ester 
• 174635-51-9 (R,S)-N-[α-(methoxycarbonyl)benzyl]-2-phenylquinoline-4-carboxamide 
• 220437-96-7 methyl 2-<(trimethylsilyl)methyl>amino-2-phenylacetate 
• 192062-90-1 2-(3-benzylureido)-2-phenylacetic acid methyl ester 
• 200356-39-4 Allylamino-phenyl-acetic acid methyl ester 
• 21735-58-0 methyl N-trifluoroacetylphenylglycinate 
• 153924-62-0 N-benzylidenephenylglycine methyl ester 

Relevant articles and documents

Synthesis of 3-Hydroxymethyl Isoindolinones via Cobalt-Catalyzed C(sp2)-H Carbonylation of Phenylglycinol Derivatives

An efficient method for the synthesis of 3-hydroxymethyl isoindolinones via cobalt-catalyzed C(sp2)-H carbonylation of phenylglycinol derivatives using picolinamide as a traceless directing group is demonstrated. The reaction proceeds in the presence of a commercially available cobalt(II) tetramethylheptanedionate catalyst and employs DIAD as a "CO" surrogate. This synthetic route offers a broad substrate scope, excellent regioselectivity, and full preservation of the original stereochemistry. Besides, the developed method provides a pathway for accessing valuable enantiopure 3-substituted isoindolinone derivatives.

Synthesis of unnatural α-amino acid derivatives: Via selective o -C-H functionalization

Pd-Catalyzed o-C-H functionalization of α-phenylglycine, 4-hydroxyphenylglycine and phenylalanine using picolinamide as a directing group is reported. We have developed different protocols for the arylation, alkylation, alkynylation, halogenation, alkoxylation, and acyloxylation of these amino acids. The reactions exhibit high selectivity, broad substrate scope, and compatibility with different functional groups in moderate to high yields. They provide a rapid and efficient access to a variety of phenyl based amino acid derivatives which can be further modified and have broad spectrum of applications in medicinal chemistry.

Treatment of proliferative disorders with a chemiluminescent agent

Methods employing chemiluminescent agents as therapeutically active agents in the treatment of proliferative disorders are disclosed. The chemiluminiscent agents are used in the disclosed method without a therapeutically effective amount of a photosensitizer. Novel chemiluminescent agents having the general formula: are also disclosed, wherein X, Y, Z, R3 and R5-R9 are as defined herein.