258873-45-9

Upstream product

• 1079-66-9 chloro-diphenylphosphine 
• 259136-24-8 3,4-O-isopropylidene-(3S,4S)-dihydroxy-(2S,5S)-hexanediol bis(methanesulfonate) 
• 132014-09-6 2,2-dimethyl-4,5-di(2-oxiranyl)-1,3-dioxolane 
• 63699-97-8 1,2:5,6-dianhydro-3,4-O-methylethylidene-L-iditol 
• 51432-64-5 1,6-di-O-benzoyl-3,4-di-O-isopropylidene-D-mannitol 
• 829-85-6 diphenylphosphane 
• 3969-84-4 3,4-di-O-isopropylidene-D-mannitol 
• 51432-65-6 1,6-di-O-benzoyl-3,4-O-isopropylidene-2,5-di-O-p-toluenesulphonyl-D-mannitol 
• 159716-52-6 (2S,3R,4R,5S)-3,4-O-(1-methylethylidene)-2,3,4,5-hexanetetraol 

Relevant academic research and scientific papers

Ligand substituent effects on asymmetric induction. Effect of structural variations of the DIOP ligand on the Rh-catalyzed asymmetric hydrogenation of enamides

(equation presented) Substituent changes in the ligand (L*) backbone and the chelating phosphorus atoms of the classical DIOP ligand result in dramatic changes in the enantioselectivity of Rh+L*-catalyzed enamide hydrogenations.

Highly Flexible Synthetic Routes to Functionalized Phospholanes from Carbohydrates

Highly functionalized phospholanes 15, 17, and 26 and the corresponding diastereomers in which the configurations of the phospholane carbon-2 and carbon-5 are inverted can be readily prepared from D-mannitol by displacement of the appropriate dimesylate or cyclic sulfate with dilithium-phosphide reagents. The diols from which these ligands are prepared can also be converted into diarylphosphinite ligands. A route to related monophosphines bearing hemilabile tert-butylthio groups is also described. Complexes of these ligands and of related deprotected derivatives are potentially useful for enantioselective catalysis in organic and aqueous media.