258874-61-2Relevant academic research and scientific papers
A general and efficient 2-amination of pyridines and quinolines
Yin, Jingjun,Xiang, Bangping,Huffman, Mark A.,Raab, Conrad E.,Davies, Ian W.
, p. 4554 - 4557 (2008/02/04)
(Chemical Equation Presented) Pyridine N-oxides were converted to 2-aminopyridines in a one-pot fashion using Ts2O-t-BuNH2 followed by in situ deprotection with TFA. The amination proceeded in high yields, excellent 2-/4-selectivity, and with good functional group compatibility. 2-Amino (iso)quinolines were also obtained in the same manner. Combined with the simple oxidation of pyridines to pyridine N-oxides, this method provides a general and efficient way for amination of 2-unsubstituted pyridines.
A new facile method for the synthesis of 4-dialkylaminopyridine derivatives by high-pressure-promoted amination of 4-chloropyridine
Kotsuki, Hiyoshizo,Sakai, Hiromitsu,Shinohara, Toshio
, p. 116 - 118 (2007/10/03)
A new method for synthesizing 4-(di)alkylaminopyridine derivatives in high yield was established by the high-pressure-promoted nucleophilic aromatic substitution of 4-chloropyridine with various primary/secondary amines.
