258878-68-1

Basic information

• Product Name: 4-[2-[2-[3-(Biphenyl-4-yl)-5-methyl-4H-1,2,4-triazol-4-yl]phenoxy]ethyl]morpholine
• CAS NO: 258878-68-1
• Molecular Formula: C₂₇H₂₈N₄O₂
• Molecular Weight: 440.54981
• Mol File: 258878-68-1.mol

Chemical Properties

• CAS DataBase Reference: 4-[2-[2-[3-(Biphenyl-4-yl)-5-methyl-4H-1,2,4-triazol-4-yl]phenoxy]ethyl]morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-[2-[3-(Biphenyl-4-yl)-5-methyl-4H-1,2,4-triazol-4-yl]phenoxy]ethyl]morpholine(258878-68-1)
• EPA Substance Registry System: 4-[2-[2-[3-(Biphenyl-4-yl)-5-methyl-4H-1,2,4-triazol-4-yl]phenoxy]ethyl]morpholine(258878-68-1)

Safety Data

• Hazardous Substances Data: 258878-68-1(Hazardous Substances Data)

Upstream product

• 3647-69-6 4-(2-chloroethyl)morpholine hydrochride 
• 258878-31-8 5-(4-biphenyl)-4-(2-hydroxyphenyl)-3-methyl-1,2,4-triazole 
• 18622-23-6 4-phenylbenzohydrazide 
• 20012-63-9 o-(benzyloxy)aniline 
• 34288-19-2 N-(2-(benzyloxy)phenyl)acetamide 
• 14002-51-8 4-biphenyl-carboxylic acid chloride 
• 258879-14-0 2-(benzyloxy)thioacetanilide 
• 258878-27-2 4-(2-benzyloxy)-5-(4-biphenyl)-3-methyl-1,2,4-triazole 
• 92-92-2 biphenyl-4-carboxylic acid 

Relevant articles and documents

Discovery of 4,5-diphenyl-1,2,4-triazole derivatives as a novel class of selective antagonists for the human V(1A) receptor.

In the search for a novel class of selective antagonists for the human V(1A) receptor, high-throughput screening (HTS) of the Yamanouchi chemical library using CHO cells expressing the cloned human V(1A) (hV(1A)) receptor led to the discovery of 5-(4-biphenyl)-4-(2-methoxyphenyl)-3-methyl-1,2,4-triazole (3) which possessed the novel 4,5-diphenyl-1,2,4-triazole structure. Subsequent structure-activity relationships studies on a series of the 4,5-diphenyl-1,2,4-triazole derivatives related to 3 revealed that the 4,5-diphenyl-1,2,4-triazole structure played an essential role in exerting high affinity for the hV(1A) receptor and that introduction of a basic amine moiety to the methoxy part of the 4-phenyl ring was effective in the improvement of both affinity for the hV(1A) receptor and selectivity versus the hV(2) receptor. Compound 3 and the 2-(morphorino)ethoxy derivative (11b) were shown to be antagonists for the hV(1A) receptor, from their effects on AVP-induced [Ca(2+)](i) response in CHO cells expressing the hV(1A) receptor.