25890-80-6Relevant academic research and scientific papers
Biocatalytic preparation of dichloropropyl acrylates. Application to the synthesis of poly(dichloropropyl acrylates)
Edinson, Yara-Varon,Jordi, Eras Joli,Merce, Torres,Merce, Balcells,Gemma, Villorbina,Ramon, Canela-Garayoa
, p. 7 - 13 (2013/07/19)
The synthesis of dichloropropyl acrylates from dichloropropyl dodecanoates through a transesterification process using diverse commercial lipases and whole cells (fungal resting cells) is presented. The synthesis was carried out in a solvent-free media using a conventional batch system and a packed bed reactor (PBR). The effect of water activity on the process depended on the lipase used. The commercial enzyme CALB (Candida antarctica lipase B immobilized onto a macroporous acrylic resin) showed the best performance as a biocatalyst, achieving a yield of 50% and productivity of 7.2 μmol min-1 g -1 in the batch reactor and 33% and 35.8 μmol min-1 g-1 in the PBR. Finally, polymeric material was prepared by suspension polymerization of the dichloropropyl acrylates synthesized using PBR. Particles with diameters between 170 and 380 μm were obtained with a yield of 85% after 18 h reaction. AbbreviationsPBRpacked bed reactorCALBCandida antarctica lipase B immobilized onto a macroporous acrylic resin.
Solvent-free biocatalytic interesterification of acrylate derivatives
Yara-Varón, Edinson,Eras Joli, Jordi,Torres, Mercè,Sala, Nuria,Villorbina, Gemma,Méndez, Jonh Jairo,Canela-Garayoa, Ramon
, p. 86 - 90 (2013/01/15)
The ability of diverse commercial lipases and whole cells (fungal resting cells) to synthesise allyl and dichloropropyl acrylate from allyl dodecanoate through an interesterification process is presented. The process was carried out without solvent in a conventional batch system. The best biocatalyst among those studied was the commercial enzyme CALB (Candida antarctica lipase B immobilised onto a macroporous acrylic resin). The reaction was sensitive to water activity, and a decrease in the yield was observed at the highest activity studied. CALB could also be applied to diverse acrylic derivatives, although the yields decreased using either ethyl methacrylate or acrylic acid.
