25892-09-5 Usage
Uses
Used in Dye and Pigment Production:
2,6-difluoro-3-nitroaniline is used as a key intermediate in the synthesis of dyes and pigments, contributing to the development of colorants with specific properties required for various applications.
Used in Agricultural Chemicals:
In the agricultural industry, 2,6-difluoro-3-nitroaniline is used as an intermediate for the production of various chemicals that aid in crop protection and enhancement of agricultural yields.
Used in Pharmaceutical Industry:
2,6-difluoro-3-nitroaniline is employed as an intermediate in the synthesis of pharmaceutical compounds, playing a crucial role in the development of new drugs with potential therapeutic applications.
Safety Precautions:
Given its toxic nature and potential harmful effects if ingested or inhaled, as well as its ability to cause skin and eye irritation, 2,6-difluoro-3-nitroaniline requires careful handling and adherence to proper safety procedures during its use in various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 25892-09-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,8,9 and 2 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 25892-09:
(7*2)+(6*5)+(5*8)+(4*9)+(3*2)+(2*0)+(1*9)=135
135 % 10 = 5
So 25892-09-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H4F2N2O2/c7-3-1-2-4(10(11)12)5(8)6(3)9/h1-2H,9H2
25892-09-5Relevant academic research and scientific papers
Site-Selective Copper-Catalyzed Amination and Azidation of Arenes and Heteroarenes via Deprotonative Zincation
Hendrick, Charles E.,Bitting, Katie J.,Cho, Seoyoung,Wang, Qiu
supporting information, p. 11622 - 11628 (2017/08/30)
Arene amination is achieved by site-selective C-H zincation followed by copper-catalyzed coupling with O-benzoylhydroxylamines under mild conditions. Key to this success is ortho-zincation mediated by lithium amidodiethylzincate base that is effective for a wide range of arenes, including nonactivated arenes bearing simple functionalities such as fluoride, chloride, ester, amide, ether, nitrile, and trifluoromethyl groups as well as heteroarenes including indole, thiophene, pyridine, and isoquinoline. An analogous C-H azidation is also accomplished using azidoiodinane for direct introduction of a useful azide group onto a broad scope of arenes and heteroarenes. These new transformations offer rapid access to valuable and diverse chemical space of aminoarenes. Their broad applications in organic synthesis and drug discovery are demonstrated in the synthesis of novel analogues of natural product (-)-nicotine and antidepressant sertraline by late-stage amination and azidation reactions.
