25899-96-1

Upstream product

• 24393-61-1 ethyl (E)-3-(4-nitrophenyl)-2-propenoate 
• 32868-25-0 2-(4-amminofenil)propionico d'etile 
• 108-24-7 acetic anhydride 
• 5438-70-0 ethyl (4-amino-3,5-dibromophenyl)acetate 
• 36691-06-2 ethyl 2-(4-(1,3-dioxoisoindolin-2-yl)phenyl)acetate 
• 36691-05-1 2-(4-phthalimido-phenyl)-propionic acid ethyl ester 

Downstream Products

• 726206-83-3 C₁₃H₁₆N₂O₅ 

Relevant academic research and scientific papers

Design, synthesis and SAR of novel ethylenediamine and phenylenediamine derivatives as factor Xa inhibitors

We previously reported on a series of cyclohexanediamine derivatives as highly potent factor Xa inhibitors. Herein, we describe the modification of the spacer moiety to discover an alternative scaffold. Ethylenediamine derivatives possessing a substituent at the C1 position in S configuration and phenylenediamine derivatives possessing a substituent at the C5 position demonstrated moderate to strong anti-fXa activity. Further SAR studies led to the identification of compound 30h which showed both good in vitro activity (fXa IC50 = 2.2 nM, PTCT2 = 3.9 μM) and in vivo antithrombotic efficacy.

Benzene derivatives having NGF production-promoting activity

A compound of the formula (I): STR1 wherein R1 is an unsubstituted or substituted amino group, a protected amino group, or a nitro group; R2 is an unsubstituted or substituted amino group, a protected amino group, an unsubstituted or substituted hydroxy group or a protected hydroxy group; R3 is an unsubstituted or substituted amino group, m is 0 to 2; n is 0 to 6; with the proviso that when m is 0, then n is an integer from 2 to 6, and pharmaceutically acceptable salts thereof. Compounds of formula (I) except those wherein R1 is a nitro group have activity in promoting the production of nerve growth factor.

Immunomodulating agent

Phenylacetic acid derivatives of the formula: STR1 wherein R1 is hydrogen or STR2 wherein R5 is an alkyl group of 1-6 carbon atoms or an aryl group; R2 and R3 are independently hydrogen or an alkyl group of 1-4 carbon atoms; R4 is hydrogen or an alkyl group of 1-4 carbon atoms, have been found to possess immunomodulating activity.

Tertiary aminoacids

New α-(cyclic tert. aminophenyl)-aliphatic acids, e.g. those of the formula STR1 and functional derivatives thereof, are anti-inflammatory agents.

Tertiary aminoacids

New α-(cyclic tert. aminophenyl)-aliphatic acids, e.g. those of the formula STR1 AND FUNCTIONAL DERIVATIVES THEREOF, ARE ANTI-INFLAMMATORY AGENTS.