259092-15-4Relevant articles and documents
Preparation and separation method of isopropyltropine isomers
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Paragraph 0024; 0034-0035; 0036-0037; 0038-0039; 0040-0043, (2019/08/12)
The invention discloses a preparation and separation method of isopropyltropine isomers. The method comprises the following steps: performing reduction on a compound represented by a formula (1) shownin the description in an organic solvent, performing post-treatment to obtain a compound represented by a formula (2) shown in the description, performing a reaction on the compound represented by the formula (2) and a compound represented by a formula (3) shown in the description in an organic solvent under the catalysis of a base, performing post-treatment to obtain a compound represented by aformula (4) shown in the description, and performing separation on the compound represented by the formula (4) to obtain the pure compounds represented by a formula (5) and (6) shown in the description. The method provided by the invention is simple, convenient and easy to implement, the raw materials are easy to obtain, and the operation steps are simple and short, and the compounds represented by the formula (5) and (6) obtained after column chromatography separation can meet requirements in a laboratory.