259100-43-1

Upstream product

• 53874-66-1 3-phenoxybenzyl chloride 
• 259100-47-5 2-amino-5-(benzylsulfanyl)[1,3]thiazolo[4,5-d]pyrimidin-7-ol 
• 259103-40-7 {[4-amino-2-(benzylsulfanyl)-6-hydroxypyrimidin-5-yl]sulfanyl}formonitrile 
• 127199-95-5 2-amino-5-mercapto-thiazolo[4,5-d]pyrimidin-7-ol 

Downstream Products

• 259100-42-0 5-[[(3-Phenoxyphenyl)methyl]thio]thiazolo[4,5-d]pyrimidin-7(4H)-one 
• 259103-42-9 7-chloro-5-[[(3-phenoxyphenyl)methyl]thio]thiazolo[4,5-d]pyrimidin-2-amine 

Relevant academic research and scientific papers

Hit-to-Lead studies: The discovery of potent, orally bioavailable thiazolopyrimidine CXCR2 receptor antagonists

A Hit-to-Lead optimisation programme was carried out on a high throughput screening hit, the thiazolopyrimidine 1, resulting in the discovery of the potent, orally bioavailable CXCR2 antagonist 29.

NOVEL THIAZOLOPYRIMIDINE COMPOUNDS

The invention provides certain thiazolopyrimidine compounds, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.