Hit-to-Lead studies: The discovery of potent, orally bioavailable thiazolopyrimidine CXCR2 receptor antagonists

DOI: 10.1016/j.bmcl.2005.10.091

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 960 - 963 (2006)

Update date:2022-08-02

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Authors:

Baxter, Andrew

Cooper, Anne

Kinchin, Elizabeth

Moakes, Kerry

Unitt, John

Wallace, Alan

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Article abstract of DOI:10.1016/j.bmcl.2005.10.091

A Hit-to-Lead optimisation programme was carried out on a high throughput screening hit, the thiazolopyrimidine 1, resulting in the discovery of the potent, orally bioavailable CXCR2 antagonist 29.

Full text of DOI:10.1016/j.bmcl.2005.10.091

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