259136-28-2Relevant academic research and scientific papers
Highly Flexible Synthetic Routes to Functionalized Phospholanes from Carbohydrates
Yan, Yuan-Yong,RajanBabu
, p. 900 - 906 (2007/10/03)
Highly functionalized phospholanes 15, 17, and 26 and the corresponding diastereomers in which the configurations of the phospholane carbon-2 and carbon-5 are inverted can be readily prepared from D-mannitol by displacement of the appropriate dimesylate or cyclic sulfate with dilithium-phosphide reagents. The diols from which these ligands are prepared can also be converted into diarylphosphinite ligands. A route to related monophosphines bearing hemilabile tert-butylthio groups is also described. Complexes of these ligands and of related deprotected derivatives are potentially useful for enantioselective catalysis in organic and aqueous media.
