259144-38-2

Upstream product

• 3744-87-4 N-t-butyloxycarbonyl-DL-alanine 
• 719-59-5 5-chloro-2-aminobenzophenone 

Downstream Products

• 1295585-09-9 N-(2-benzoyl-4-chlorophenyl)-alaninamide hydrochloride 
• 4699-82-5 7-chloro-1,3-dihydro-3-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one 

Relevant academic research and scientific papers

2-Acylamino-5-chlorobenzophenones with enhanced selectivity towards malaria parasites

Previously we described a series of 5-acylaminobenzophenones with considerable antimalarial activity. Unfortunately, most compounds also displayed high cytotoxicity resulting in low selectivity towards malaria parasites. Through the replacement of the 5-acylamino moiety by simple chlorine and further modifications of the 2-acylamino residue we could obtain inhibitors with improved selectivity towards malaria parasites combined with an acceptable reduction of antimalarial activity.