259151-39-8Relevant academic research and scientific papers
Use of readily available chiral compounds related to the Betti base in the enantioselective addition of diethylzinc to aryl aldehydes
Cardellicchio, Cosimo,Ciccarella, Giuseppe,Naso, Francesco,Perna, Filippo,Tortorella, Paolo
, p. 14685 - 14692 (1999)
Readily available members of the family of chiral non-racemic aminonaphthols related to the Betti base 1 were tested as complexing agents in the catalytic enantioselective addition of diethylzinc to aryl aldehydes. The use of these bases gave high ee values (up to >99%). The highest ee values were obtained with the tertiary aminonaphthol 2. An important role was played by the solvent. The effect of the nature and the position of the substituents on the aromatic ring of the aldehyde was also investigated.
Highly regioselective N-alkylation of nonracemic Betti base: A novel one-pot synthesis of chiral N-methyl-N-alkyl Betti bases
Dong, Yanmei,Sun, Jianwei,Wang, Xinyan,Xu, Xuenong,Cao, Liya,Hu, Yuefei
, p. 1667 - 1672 (2007/10/03)
A novel one-pot preparation of chiral N-methyl-N-alkyl Betti bases has been developed involving a highly regioselective N-alkylation of (S)-(+)-Betti base. The strategy involved formation-cleavage of the oxazine ring and N-methylation with BtCH2/sub
