219897-38-8Relevant articles and documents
The Betti base: Absolute configuration and routes to a family of related chiral nonracemic bases
Cardellicchio, Cosimo,Ciccarella, Giuseppe,Naso, Francesco,Schingaro, Emanuela,Scordari, Fernando
, p. 3667 - 3675 (1998)
A detailed protocol for the resolution of the Betti base [i.e. 1-(α- aminobenzyl)-2-naphthol] was investigated and the absolute configuration of the two isomers was established by means of an X-ray diffractometric study. A series of optically active deriv
Optically pure 1 - (α-aminobenzyl) - 2-naphthol preparation method
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Paragraph 0054; 0055, (2017/04/11)
The invention provides a preparation method of optical pure 1-(alpha-amino benzyl)-2-naphthol. The preparation method comprises the following steps: catalytically synthesizing racemic 1-(alpha-amino benzyl)-2-naphthol trifluoroacetate by utilizing trifluoroacetic acid; and splitting racemic 1-(alpha-amino benzyl)-2-naphthol and trifluoroacetate thereof by utilizing optical pure 1, 1'-binaphthol phosphate ester and optical pure 1, 1'-binaphthol sodium phosphate as splitting reagents to prepare optical pure 1-(alpha-amino benzyl)-2-naphthol. The method is good in repeatability, and the splitting reagents can be repeatedly used, so that the method is low in cost, environment-friendly and energy-saving, and suitable for large-scale preparation of optical pure 1-(alpha-amino benzyl)-2-naphthol.
A new method for the synthesis of enantiomerically pure Betti base
Bian, Guangling,Yang, Shiwei,Huang, Huayin,Song, Ling
, p. 899 - 902 (2013/05/22)
We have developed a new method for the synthesis of enantiomerically pure Betti base. By using trifluoroacetic acid to replace the more traditionally used hydrochloride acid, the hydrolysis procedure used in the classical synthesis of racemic Betti base was carried out under milder conditions with an improved yield (up to 96%), which was followed by a new and efficient resolution with using recyclable (R)-1,1′-binaphthalene-2,2′-diyl sodium phosphate to provide enantiomerically pure (S)-Betti base in 95% yield with up to 99% ee and (R)-Betti base in 93% yield with 90% ee in one resolution step. Georg Thieme Verlag Stuttgart - New York.