25917-55-9Relevant academic research and scientific papers
A Novel Ketonitrile Synthesis by Palladium-Catalyzed Carbonylative Coupling Reactions of Amides with Arylboronic Acids
Mai, Wen-Peng,Liu, Yang,Sui, Hong-Dai,Xiao, Yong-Mei,Mao, Pu,Lu, Kui
supporting information, p. 7814 - 7819 (2019/12/24)
A novel, efficient, and simple procedure to synthesize diverse ketonitriles by palladium-catalyzed Suzuki coupling of amides through N–C cleavage has been developed. This procedure features mild conditions, a broad substrate scope, and easily prepared substrates, providing a simple and efficient access to a variety of ketonitriles.
Nickel/Photoredox-Catalyzed Amidation via Alkylsilicates and Isocyanates
Zheng, Shuai,Primer, David N.,Molander, Gary A.
, p. 7957 - 7961 (2017/11/10)
A nickel/photoredox, dual-catalyzed amidation reaction between alkylsilicate reagents and alkyl/aryl isocyanates is reported. In contrast to the previously reported reductive coupling process, this protocol is characterized by mild reaction conditions and the absence of a stoichiometric reductant. A mechanistic hypothesis involving a nickel-isocyanate adduct is proposed based on literature precedent and further validation by experimental results.
Selective palladium-catalyzed aminocarbonylation of olefins with aromatic amines and nitroarenes
Fang, Xianjie,Jackstell, Ralf,Beller, Matthias
, p. 14089 - 14093 (2014/01/06)
Various olefins can be smoothly transformed in the presence of a Pd-based catalyst system and (hetero)aromatic amines or nitroarenes to synthetically interesting amides in good yields and often with high regioselectivity (see scheme). Combining this atom-efficient procedure with established functionalizations of the resulting products allows the efficient preparation of quinolines. Copyright
Synthesis and application of modular phosphine-phosphoramidite ligands in asymmetric hydroformylation: Structure-selectivity relationship
Zhang, Xiaowei,Cao, Bonan,Yan, Yongjun,Yu, Shichao,Ji, Baoming,Zhang, Xumu
experimental part, p. 871 - 877 (2010/06/20)
A series of hybrid phos- phine-phosphoramidite ligands has been designed and synthesized in moderate yields from chiral BINOL (1, 1′- bi-2-naphthol) or NOBIN (2-amino-2′- hydroxy-1, 1′-binaphthyl). They have achieved highly regio- and enantiose- lectivities in Rh-catalyzed asymmetric hydroformylations of styrene derivatives (branched/linear ratio up to 56.6, ee up to 99%), vinyl acetate derivatives (up to 98% ee), and allyl cyanide (up to 96 % ee). Systematic variation of ligand structure showed that the steric factor on the phsophoramidite moiety determined the performance of the ligand. With the increased hindrance, the branched/linear ratio rose, while the ee value dropped in the hydrofor- mylation of styrene. However, the N- substituents did not influence the selec- tivities much.
