259183-84-1

Basic information

• Product Name: [2-(morpholin-4-yl)ethoxy]benzene-4-sulfonyl chloride
• Synonyms: [2-(morpholin-4-yl)ethoxy]benzene-4-sulfonyl chloride
• CAS NO: 259183-84-1
• Molecular Weight: 305.782
• Mol File: 259183-84-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [2-(morpholin-4-yl)ethoxy]benzene-4-sulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(morpholin-4-yl)ethoxy]benzene-4-sulfonyl chloride(259183-84-1)
• EPA Substance Registry System: [2-(morpholin-4-yl)ethoxy]benzene-4-sulfonyl chloride(259183-84-1)

Safety Data

• Hazardous Substances Data: 259183-84-1(Hazardous Substances Data)

Upstream product

• 1209-10-5 4-(2-phenoxyethyl)morpholine 
• 29488-54-8 4-(2-phenoxyethyl)-morpholine hydrochloride 

Downstream Products

• 259183-29-4 1-[{2-(morpholin-4-yl)ethoxy}phenyl-4-sulfonyl]-2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole 
• 259183-38-5 1-[{2-(morpholin-4-yl)ethoxy}phenyl-4-sulfonyl]-2-[(3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methylsulfinyl]-1H-benzimidazole 

Relevant articles and documents

Prodrugs of proton pump inhibitors

Prodrugs of the pyridyl methyl sulfinyl benzimidazole type proton pump inhibitor drugs have a hydrolyzable arylsulfonyl or heteroarylsulfonyl group attached to the benzimidazole nitrogen. The prodrugs of the invention hydrolyze under physiological conditions to provide the proton pump inhibitors with a half life measurable in hours, and are capable of providing sustained plasma concentrations of the proton pump inhibitor drugs for longer time than presently used drugs. The generation of the proton pump inhibitor drugs from the prodrugs of the invention under physiological conditions allows for more effective treatment of several diseases and conditions caused by gastric acid secretion.