1209-10-5

Basic information

• Product Name: 4-(2-phenoxyethyl)Morpholine
• Synonyms: 4-(2-phenoxyethyl)Morpholine
• CAS NO: 1209-10-5
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.26888
• Mol File: 1209-10-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(2-phenoxyethyl)Morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-phenoxyethyl)Morpholine(1209-10-5)
• EPA Substance Registry System: 4-(2-phenoxyethyl)Morpholine(1209-10-5)

Safety Data

• Hazardous Substances Data: 1209-10-5(Hazardous Substances Data)

Upstream product

• 622-40-2 2-(morpholin-4-yl)ethanol 
• 105-58-8 Diethyl carbonate 
• 108-95-2 phenol 
• 3647-69-6 4-(2-chloroethyl)morpholine hydrochride 

Downstream Products

• 259183-84-1 [2-(morpholin-4-yl)ethoxy]benzene-4-sulfonyl chloride 
• 259183-83-0 4-(3-morpholinopropoxy)benzene-1-sulfonyl chloride 
• 120180-42-9 Perfluoro<4-(2-cyclohexyloxyethyl)morpholine> 

Relevant articles and documents

Mustard Carbonate Analogues as Sustainable Reagents for the Aminoalkylation of Phenols

N,N-dialkyl ethylamine moiety can be found in numerous scaffolds of macromolecules, catalysts, and especially pharmaceuticals. Common synthetic procedures for its incorporation in a substrate relies on the use of a nitrogen mustard gas or on multistep syntheses featuring chlorine hazardous/toxic chemistry. Reported herein is a one-pot synthetic approach for the easy introduction of aminoalkyl chain into different phenolic substrates through dialkyl carbonate (β-aminocarbonate) chemistry. This new direct alcohol substitution avoids the use of chlorine chemistry, and it is efficient on numerous pharmacophore scaffolds with good to quantitative yield. The cytotoxicity via MTT of the β-aminocarbonate, key intermediate of this synthetic approach, was also evaluated and compared with its alcohol precursor.