259185-93-8Relevant academic research and scientific papers
Synthesis of Optically Active Atropisomeric Anilide Derivatives through Diastereoselective N-Allylation with a Chiral Pd-π-Allyl Catalyst
Kitagawa, Osamu,Takahashi, Masashi,Kohriyama, Mitsuteru,Taguchi, Takeo
, p. 9851 - 9853 (2007/10/03)
N-Allylation of o-tert-butyl anilides derived from o-tert-butyl aniline and (S)-lactic acid or (S)-mandelic acid proceeded with high diastereoselectivity in the presence of a (BINAP)Pd-π-allyl catalyst to give atropisomeric N-allyl o-tert-butyl anilide de
Efficient synthesis of various atropisomeric amides in optically pure forms and their application to asymmetric reactions
Kitagawa, Osamu,Momose, Shu-ichi,Fushimi, Yoshihisa,Taguchi, Takeo
, p. 8827 - 8831 (2007/10/03)
Various atropisomeric amides were prepared in optically pure forms (≥98% ee) through the optical resolution of the amide ester derived from (R)-pantolactone, N-allyl-ortho-tert-butylaniline and oxalyl chloride. Asymmetric carbonyl addition reaction of an alkyllithium and asymmetric iodolactonization with these atropisomeric amides proceeded with high stereoselectivity.
