259191-90-7

Upstream product

• 58378-23-7 toluene-4-sulfonic acid-(1-methyl-4-phenyl-butyl ester) 
• 2344-71-0 5-phenylpentan-2-ol 
• 637-59-2 1-Bromo-3-phenylpropane 
• 63790-07-8 1-methyl-4-phenylbutyl methanesulphonate 

Downstream Products

• 259191-91-8 5-amino-1-(1-methyl-4-phenyl-butyl)-1H-[1,2,3]triazole-4-carboxamide 
• 259191-60-1 5-Benzyl-3-(1-methyl-4-phenyl-butyl)-3,6-dihydro-[1,2,3]triazolo[4,5-d]pyrimidin-7-one 
• 259191-58-7 3-(1-Methyl-4-phenyl-butyl)-5-pyridin-4-ylmethyl-3,6-dihydro-[1,2,3]triazolo[4,5-d]pyrimidin-7-one 
• 259191-67-8 5-(Hydroxy-phenyl-methyl)-3-(1-methyl-4-phenyl-butyl)-3,6-dihydro-[1,2,3]triazolo-[4,5-d]pyrimidin-7-one 
• 259191-72-5 5-Benzoyl-3-(1-methyl-4-phenyl-butyl)-3,6-dihydro-[1,2,3]triazolo[4,5-d]pyrimidin-7-one 
• 259191-63-4 5-(4-Methoxy-benzyl)-3-(1-methyl-4-phenyl-butyl)-3,6-dihydro-[1,2,3]triazolo[4,5-d]pyrimidin-7-one 
• 259191-62-3 5-(4-Chloro-benzyl)-3-(1-methyl-4-phenyl-butyl)-3,6-dihydro-[1,2,3]triazolo[4,5-d]pyrimidin-7-one 
• 259191-83-8 3-(1-Methyl-4-phenyl-butyl)-5-[4-(4-methyl-piperazine-1-sulphonyl)-benzyl]-3,6-dihydro-[1,2,3]triazolo[4,5-d]pyrimidin-7-one 
• 259191-61-2 5-(3,4-Dimethoxy-benzyl)-3-(1-methyl-4-phenyl-butyl)-3,6-dihydro-[1,2,3]triazolo-[4,5-d]pyrimidin-7-one 
• 259191-78-1 N-(2-Dimethylamino-ethyl)-3-[3-(1-methyl-4-phenyl-butyl)-7-oxo-6,7-dihydro-3H-[1,2,3]triazolo [4,5-d]pyrimidin-5-ylmethyl]benzenesulphonamide 
• 259191-74-7 3-(1-Methyl-4-phenyl-butyl)-5-[3-(morpholine-4-sulphonyl)-benzyl]-3,6-dihydro[1,2,3]triazolo[4,5-d]pyrimidin-7-one 

Relevant academic research and scientific papers

A straightforward and versatile approach to the synthesis of 1,4,5-trisubstituted 1,2,3-triazoles from alkyl halides via a one-pot, three-component reaction

The preparation of 1,4,5-trisubstituted 1,2,3-triazoles by the coupling of three components (alkyl halides, sodium azide, and active ketones) through an azide-enolate [3+2] cycloaddition (Dimroth cycloaddition) has been developed for the first time. A wide variety of halides (including chlorides, bromides, and iodides as well as primary and secondary derivatives) have demonstrated the versatility of this method, which is based on a one-pot system under mild reaction conditions.

A soluble iron(ii)-phthalocyanine-catalyzed intramolecular C(sp3)-H amination with alkyl azides

Herein, we describe a soluble iron(ii)-phthalocyanine, [FeII(tBu4Pc)(py)2] (Pc = phthalocyaninato(2-)), as an effective catalyst in intramolecular C(sp3)-H bond amination, with alkyl azides as the nit

Dihydro-[1,2,3]triazolo-[4,5-d]pyrimidin-7-one

The present invention relates to novel dihydro-[1,2,3]triazolo-[4,5-d]pyrimidin-7-one, to processes for their preparation and to their use as medicaments, in particular as inhibitors of cGMP-metabolizing phosphodiesterases.