63790-07-8

Upstream product

• 2344-71-0 5-phenylpentan-2-ol 
• 3360-41-6 4-phenyl-butan-1-ol 
• 637-59-2 1-Bromo-3-phenylpropane 
• 129235-00-3 6-phenyl-2S-hexanol 
• 2344-71-0 (S)-(+)-5-phenyl-2-pentanol 
• 73494-49-2 (2R)-5-Phenyl-2-pentanol 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 63789-85-5 2,3-dihydro-2,2-dimethyl-5-hydroxy-7-(1-methyl-4-phenylbutoxy)-4H-1-benzopyran-4-one 
• 69025-98-5 (+/-)-6,6aβ,7,8,10,10aα-hexahydro-6,6-dimethyl-3-(1-methyl-4-phenylbutoxy)-9H-dibenzopyran-9-one 
• 63789-90-2 2,3-dihydro-5-hydroxy-3-(hydroxymethylene)-2,2-dimethyl-7-(1-methyl-4-phenylbutoxy)-4H-1-benzopyran-4-one 
• 69025-89-4 (6aR,10aR)-1-Amino-6,6-dimethyl-3-(1-methyl-4-phenyl-butoxy)-6,6a,7,8,10,10a-hexahydro-benzo[c]chromen-9-one 
• 69025-90-7 (+/-)-1-amino-6aβ,7,8,9,10,10aα-hexahydro-6,6-dimethyl-3-(1-methyl-4-phenylbutoxy)-6H-dibenzopyran-9β-ol 
• 63789-94-6 (+/-)-6,6a,7,8-tetrahydro-1-hydroxy-6,6-dimethyl-3-(1-methyl-4-phenylbutoxy)-9H-dibenzopyran-9-one 
• 129657-94-9 2,3-dihydro-2,2-dimethyl-5-hydroxy-3-(3-oxobutyl)-7-(1-methyl-4-phenylbutoxy)-4H-1-benzopyran-4-one 
• 69025-92-9 (+/-)-6,6aβ,7,8,10,10aα-hexahydro-6,6-dimethyl-3-(1-methyl-4-phenylbutoxy)spiro<9H-dibenzopyran-9,2'-<1,3>dioxolane> 
• 63790-11-4 (+/-)-6,6aβ,7,8,10,10aα-hexahydro-6,6-dimethyl-3-(1-methyl-4-phenylbutoxy)spiro<9H-dibenzopyran-9,2'-<1,3>dioxolan>-1-ol 
• 69025-94-1 (+/-)-6,6aβ,7,8,10,10aα-hexahydro-6,6-dimethyl-3-(1-methyl-4-phenylbutoxy)spiro<9H-dibenzopyran-9,2'-<1,3>dioxolan>-1-amine 
• 129657-91-6 (+/-)-<6aβ,7,8,9,10,10aα-hexahydro-1,9β-dihydroxy-6,6-dimethyl-3-(1-methyl-4-phenylbutoxy)-6H-dibenzopyran-4-yl>phosphonic acid diethyl ester 
• 92358-37-7 (+/-)-6aβ,7,8,9,10,10aα-hexahydro-6,6-dimethyl-1,9-di-(phenylmethoxy)-3-(1-methyl-4-phenylbutoxy)-6H-dibenzopyran 
• 69025-91-8 phosphoric acid diethyl (+/-)-6,6aα,7,8,10,10aβ-hexahydro-6,6-dimethyl-3-(1-methyl-4-phenylbutoxy)spiro<9H-dibenzopyran-9,2'-<1,3>dioxolan>-1-yl ester 
• 69025-95-2 (+/-)-6,6aβ,7,8,10,10aα-hexahydro-6,6-dimethyl-3-(1-methyl-4-phenylbutoxy)spiro<9H-dibenzopyran-9,2'-<1,3>dioxolan>-1-yl trifluoromethanesulfonic acid ester 

Relevant academic research and scientific papers

Copper-catalyzed remote sp3 C-H chlorination of alkyl hydroperoxides

A copper-catalyzed methodology to functionalize remote sp3 C-H bonds in alkyl hydroperoxides is presented. The atom-transfer chlorination utilizes simple ammonium chloride salts as the chlorine source, and the internal redox process requires no external redox reagents.

Dihydro-[1,2,3]triazolo-[4,5-d]pyrimidin-7-one

The present invention relates to novel dihydro-[1,2,3]triazolo-[4,5-d]pyrimidin-7-one, to processes for their preparation and to their use as medicaments, in particular as inhibitors of cGMP-metabolizing phosphodiesterases.

Substituted dodecahydrotriphenylenes, decahydro-1H-cyclopenta[1]phenanthrenes, decahydro-1H-pyrido[1,2-f]phenanthridines and decahydropyrrolo[1,2-f]phenanthridines as CNS agents

1,2,3,4,4a,4b,5,6,7,8,8a,12b-Dodecahydro-7-(oxo, hydroxy or amino)-9-hydroxy-11-(alkyl, alkoxy or alkoxyalkyl)triphenylenes, 2,3,3a,3b,4,5,6,7,7a,11b-decahydro-6-(oxo, hydroxy or amino)-8-hydroxy-10-(alkyl, alkoxy or alkoxyalkyl)-1H-cyclopenta[1]phenanthrenes, 2,3,4,4a,4b,5,6,7,8,8a-decahydro-7-(oxo, hydroxy or amino)-9-hydroxy-11-(alkyl, alkoxy, alkoxyalkyl, aralkyl, aralkoxy, aryloxyalkyl or aralkoxyalkyl)-1H-pyrido[1,2-f]phenanthridines, and 1,2,3,3a,3b,4,5,6,7,7a-decahydro-6-(oxo, hydroxy or amino)-8-hydroxy-10-(alkyl, alkoxy or alkoxyalkyl)pyrrolo[1,2-f]phenanthridines and derivatives are valuable as central nervous system active agents or as intermediates to compounds having such activity.

Substituted hexahydropyrrolo[1,2-a]-quinolines, hexahydro-1H-pyrido[1,2-a]-q

Tricyclic benzo fused compounds of the formula STR1 and pharmaceutically acceptable cationic and acid addition salts thereof, wherein n is zero, 1 or 2, and t is 1 or 2; M is CH or N, R1 is H or certain acyl groups; Q is CO2 R4, COR5, C(OR7)R5 R6, CN, CONR9 R10, CH2 NR9 R10, CH2 NHCOR11, CH2 NHSO2 R12, 5-tetrazolyl or when n is 1, Q and OR1 together form a lactone or certain reduced derivatives thereof; and Z is certain alkyl, alkoxy, alkoxyalkyl, aralkyl, aralkoxy, aryloxyalkyl or aralkoxyalkyl groups, are valuable central nervous system active agents, methods for their use, pharmaceutical compositions containing them and certain intermediates therefor.

Bicyclic benzo fused compounds

Bicyclic fused benzenoid compounds of the formula STR1 and pharmaceutically acceptable cationic and acid addition salts thereof, where M is O, CH2 or NR6 ; R6 is hydrogen, formyl, carbobenzyloxy or certain carboalkoxyalkyl, alkanoyl, alkyl, aralkyl or aralkylcarbonyl groups; A' is: (1) A where one of A and B is hydrogen such that when A is hydrogen, B is C(R2 R3)(CH2)f Q and f is 1 or 2; when B is hydrogen, A is C(R2 R3)(CH2)f Q and f is 0 or 1, when taken together A and OR1 form a lactone or certain derivatives thereof; (2) A' is STR2 (3) A' is Q3 ; Q is CO2 R7, COR8, C(OH)R8 R9, CN, CONR12 R13, CH2 NR12 R13, CH2 NHCOR14, CH2 NHSO2 R17 or 5-tetrazoyl; Q3 is STR3 5-tetrazolyl, CH2 CONHCOR7, COOH or certain ester, amide, carboximido or sulfonimido derivatives thereof, CONHOH, CONHCONH2, or COCH2 Q4 where Q4 is CN or COOH or certain esters thereof; R1 is hydrogen, benzyl or certain acyl groups; R4 is hydrogen, certain alkyl or certain aralkyl groups; R5 is hydrogen or certain alkyl groups; Z is (C1 -C9)alkylene, optionally interrupted by O, S, SO or SO2 ; and W is hydrogen, methyl, certain aryl or cycloalkyl groups; useful in mammals as analgesics, tranquilizers, antiemetic agents, diuretics, anticonvulsants, antidiarrheals, antitussives, in treatment of glaucoma, and intermediates therefore.

2,10-Disubstituted dibenzo[b,d]pyrans and benzo[c]quinolines

A compound of the formula STR1 wherein Q is CH2, C=O, CHOH or CHCH2 OH; M is O or NR6 ; where R6 is hydrogen, or certain alkyl, aralkyl, acyl or carboalkoxy substituted alkyl groups; R1 is hydrogen, or certain alkanoyl or amino substituted alkanoyl groups; R4 and R5 are each hydrogen or alkyl having from 1 to 4 carbon atoms; Z is alkylene having from 1 to 9 carbon atoms or --(alk1)--X--(alk2)n -- where (alk1) and (alk2) are certain alkylene groups and X is O, S, SO or SO2 ; W is a methyl, phenyl, substituted phenyl, pyridyl, piperidyl, cycloalkyl or substituted cycloalkyl group and the pharmaceutically acceptable and addition salts of said compounds having a basic nitrogen atoms. Said compounds are useful as analgesics and as intermediates therefore.

9-Hydroxydibenzo[b,d]pyrans and intermediates

9-Hydroxydibenzo[b,d]pyrans useful as analgesics, hypotensives, immunosuppressants, tranquilizers; as anti-secretory and anti-anxiety drugs; intermediates therefor and derivatives thereof having the formulae STR1 wherein R is hydrogen or alkanoyl having from one to five carbon atoms; R1 is hydrogen, alkanoyl having from one to five carbon atoms or --CO--(CH2)P --NR2 R3 wherein p is 0 or an integer from 1 to 4; each of R2 and R3 when taken individually is hydrogen or alkyl having from one to four carbon atoms; R2 and R3 when taken together with the nitrogen to which they are attached form a 5- or 6-membered heterocyclic ring selected from piperidino, pyrrolo, pyrrolidino, morpholino and N-alkylpiperazino having from one to four carbon atoms in the alkyl group; Each of R4 and R5 is hydrogen, methyl or ethyl; R0 is oxo or alkylenedioxy having from two to four carbon atoms; Z is (a) alkylene having from one to nine carbon atoms; (b) --(alk1)m --X--(alk2)n --wherein each of (alk1) and (alk2) has from 1 to 9 carbon atoms, with the proviso that the summation of carbon atoms in (alk1) plus (alk2) is not greater than 9; Each of m and n is 0 or 1; X is O, S, SO or SO2 ; and W is methyl, phenyl, p-chlorophenyl, p-fluorophenyl, pyridyl, piperidyl, cycloalkyl having from 3 to 7 carbon atoms, or monosubstituted cycloalkyl wherein the substituent is phenyl, p-chlorophenyl or p-fluorophenyl; With the proviso that when W is methyl, Z is --(alk1)m --X---(alk2)n --.