259209-16-0Relevant academic research and scientific papers
Cyclopropene cycloadditions with annulated furans: Total synthesis of (+)- and (-)-frondosin B and (+)-frondosin A
Oblak, E.Zachary,Vanheyst, Michael D.,Li, Jin,Wiemer, Andrew J.,Wright, Dennis L.
supporting information, p. 4309 - 4315 (2014/04/03)
The asymmetric total syntheses of the natural products (+)- and (-)-frondosin B and (+)-frondosin A are reported based on a diastereoselective cycloaddition between tetrabromocyclopropene and an annulated furan to provide a highly functionalized common bu
Novel and efficient one-step parallel synthesis of dibenzopyranones via suzuki-miyaura cross coupling
Vishnumurthy, Kodumuru,Makriyannis, Alexandros
experimental part, p. 664 - 669 (2010/11/04)
Microwave-promoted novel and efficient one-step parallel synthesis of dibenzopyranones and heterocyclic analogues from bromo arylcarboxylates and o-hydroxyarylboronic acids via Suzuki-Miyaura cross coupling reaction is described. Spontaneous lactonization
Synthetic and computational studies on liphagal: A natural product inhibitor of PI-3K
Zhang, Yanzhong,Oblak, E. Zachary,Bolstad, Erin S.D.,Anderson, Amy C.,Jasinski, Jerry P.,Butcher, Ray J.,Wright, Dennis L.
experimental part, p. 6120 - 6122 (2010/12/24)
The natural product liphagal has been shown to function as a reasonably potent and selective inhibitor of the key signaling enzyme PI-3Kα. We have been interested in developing an analog class of PI-3K inhibitors based upon this unusual terpenoid natural product. Toward that end, we have evaluated the binding of the natural product to its target protein computationally and formulated a class of simplified analogs based on the structural analysis. Utilizing the cycloadduct derived from tetrabromocyclopropene and furan, we were able to generate a key, versatile scaffold upon which to pursue this analog design.
Bipyridine manganese complexes
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, (2008/06/13)
Compounds and methods of preparing compounds represented by structural formula (I): wherein X represents any suitable counter-anion; R1and R2independently represent hydrogen, C1-6alkoxy or nitro; R3, R4/su
