259222-01-0

Usage

Uses

Used in Pharmaceutical Industry:
(3-[(ACRIDINE-9-CARBONYL)-AMINO]-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER is used as a potential therapeutic agent for its fluorescent properties, which may aid in the detection and imaging of biological processes or diseases.
Used in Material Science:
In the field of material science, (3-[(ACRIDINE-9-CARBONYL)-AMINO]-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER may be utilized in the development of new materials with specific optical or electronic properties, leveraging the fluorescent characteristics of the acridine core.
Used in Organic Chemistry:
(3-[(ACRIDINE-9-CARBONYL)-AMINO]-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER serves as a protecting group in organic synthesis, used to prevent unwanted side reactions during the synthesis of more complex molecules, thus playing a crucial role in the preparation of various organic compounds.

Upstream product

• 5336-90-3 acridine-9-carboxylic acid 
• 75178-96-0 N-Boc-1,3-diaminopropane 
• 127346-48-9 N-<(tert-Butyloxy)carbonyl>propane-1,3-diamine hydrochloride 

Downstream Products

• 259221-98-2 N-(3-aminopropyl)acridine-9-carboxamide 

Relevant academic research and scientific papers

A facile route for the preparation of 9-acridinecarboxamide derivatives

The synthesis of 9-acridinecarboxamide derivatides has been improved through the choice of better reaction conditions and the devising of an original treatment step. Extended amino chains are thus easily and reliably coupled to the commercially available

Identification of ligands for the Tau exona 10 splicing regulatory element RNA by using dynamic combinatorial chemistry

We describe the use of dynamic combinatorial chemistry (DCC) to identify ligands for the stem-loop structure located at the exona 10-5′-intron junction of Tau pre-mRNA, which is involved in the onset of several tauopathies including frontotemporal dementia with Parkinsonism linked to chromosomea 17 (FTDP-17). A series of ligands that combine the small aminoglycoside neamine and heteroaromatic moieties (azaquinolone and two acridines) have been identified by using DCC. These compounds effectively bind the stem-loop RNA target (the concentration required for 50% RNA response (EC50): 2-58μM), as determined by fluorescence titration experiments. Importantly, most of them are able to stabilize both the wild-type and the +3 and +14 mutated sequences associated with the development of FTDP-17 without producing a significant change in the overall structure of the RNA (as analyzed by circular dichroism (CD) spectroscopy), which is a key factor for recognition by the splicing regulatory machinery. A good correlation has been found between the affinity of the ligands for the target and their ability to stabilize the RNA secondary structure.