25926-69-6Relevant academic research and scientific papers
Asymmetric intramolecular Cannizzaro reaction of anhydrous phenylglyoxal
Ishihara, Kazuaki,Yano, Takayuki,Fushimi, Makoto
, p. 994 - 997 (2008)
The use of anhydrous phenylglyoxal provides a solution to the problem of low reactivity in the asymmetric intramolecular Cannizzaro reaction with alcohols. Double asymmetric induction was achieved in the reaction of anhydrous phenylglyoxal with d-(+)-menthol promoted by a (S,S)-t-BuBox·copper(II) hexafluoroantimonate complex.
Highly diastereoselective reduction of (-) menthylphenylglyoxalate and (-) menthylpyruvate using new hindered lithiumtrialkoxyaluminohydrides
Boireau, G.,Deberly, A.
, p. 771 - 774 (2007/10/02)
Reduction of the keto group of (-) menthylphenylglyoxalate and (-) menthyl pyruvate can be achieved with high diastereoisomeric excess (80-90percent) using newly synthesized hindered lithium trialkoxyaluminium hydrides in THF at -78 deg C.Hindered borohydrides such as lithium trisiamylborohydride reduce those ketoesters with a lower diastereoselectivity.
