2594-12-9Relevant academic research and scientific papers
Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors
Tessier, Pierre,Smil, David V.,Wahhab, Amal,Leit, Silvana,Rahil, Jubrail,Li, Zuomei,Deziel, Robert,Besterman, Jeffrey M.
scheme or table, p. 5684 - 5688 (2010/04/30)
We have identified a series of diphenylmethylene hydroxamic acids as novel and selective HDAC class IIa inhibitors. The original hit, N-hydroxy-2,2-diphenylacetamide (6), has sub-micromolar class IIa HDAC inhibitory activity, while the rigidified oxygen a
INHIBITORS OF HISTONE DEACETYLASE
-
Page/Page column 59, (2008/12/04)
This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula compounds of the Formula (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein groups L, M, X and Y are as defined herein.
