25948-15-6

Basic information

• Product Name: 2-[N-methyl-N-(5-nitro-2-pyridyl)amino]ethanol
• Synonyms: 2-[N-methyl-N-(5-nitro-2-pyridyl)amino]ethanol;Ethanol, 2-[methyl(5-nitro-2-pyridinyl)amino]- (9CI);2-[Methyl(5-nitro-2-pyridinyl)amino]ethanol
• CAS NO: 25948-15-6
• Molecular Formula: C₈H₁₁N₃O₃
• Molecular Weight: 197.19124
• EINECS: 247-359-1
• Product Categories: PYRIDINE
• Mol File: 25948-15-6.mol
• Article Data: 8

Chemical Properties

• Melting Point: 86.5-87.5 °C
• Boiling Point: 386.4°Cat760mmHg
• Flash Point: 187.5°C
• Appearance: /
• Density: 1.345g/cm³
• Vapor Pressure: 1.16E-06mmHg at 25°C
• Refractive Index: 1.618
• PKA: 14.47±0.10(Predicted)
• CAS DataBase Reference: 2-[N-methyl-N-(5-nitro-2-pyridyl)amino]ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[N-methyl-N-(5-nitro-2-pyridyl)amino]ethanol(25948-15-6)
• EPA Substance Registry System: 2-[N-methyl-N-(5-nitro-2-pyridyl)amino]ethanol(25948-15-6)

Safety Data

• Hazardous Substances Data: 25948-15-6(Hazardous Substances Data)

Usage

General Description

2-[N-methyl-N-(5-nitro-2-pyridyl)amino]ethanol is a chemical compound that is commonly used as an antiseptic and disinfectant agent. It has broad-spectrum antibacterial and antifungal properties, and is used in pharmaceutical and personal care products. It acts by disrupting the cell membrane of microorganisms, leading to their destruction. The compound is also employed in industrial settings for the preservation of water-based products and as a biocide. Additionally, it has potential applications in the treatment of certain parasitic infections. However, it is important to handle this chemical with caution, as it may be hazardous if not used properly.

InChI:InChI=1/C8H11N3O3/c1-10(4-5-12)8-3-2-7(6-9-8)11(13)14/h2-3,6,12H,4-5H2,1H3

Upstream product

• 5418-51-9 5-nitro-2-hydroxypyridine 
• 109-83-1 (2-hydroxyethyl)(methyl)amine 
• 4548-45-2 2-chloro-5-nitropyridine 

Downstream Products

• 4928-46-5 2-((5-aminopyridin-2-yl)(methyl)amino)ethanol 
• 1419603-59-0 phenyl 6-((2-hydroxyethyl)(methyl)amino)pyridin-3-ylcarbamate 
• 1435933-31-5 C₂₀H₂₇N₃O₃ 
• 1435933-41-7 C₂₀H₂₆BrN₃O₃ 
• 1435933-40-6 C₂₄H₃₅N₃O₃ 
• 1435933-39-3 C₂₆H₃₃N₃O₃ 
• 1435933-38-2 C₁₇H₁₈F₃N₃O₃ 
• 1435933-37-1 C₁₉H₂₅N₃O₃ 
• 1435933-36-0 C₁₆H₁₉N₃O₃ 
• 1435933-35-9 C₂₀H₂₇N₃O₃ 
• 1435933-34-8 C₂₀H₂₇N₃O₃ 
• 1419599-68-0 1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(6-((2-hydroxyethyl)(methyl)amino)pyridin-3-yl)urea 

Relevant articles and documents

SUBSTITUTED HETEROAROMATIC PYRAZOLE-CONTAINING CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS

The invention relates to substituted heteroaromatic pyrazole-containing carboxamide and urea derivatives as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Discovery of potent transient receptor potential vanilloid 1 antagonists: Design and synthesis of phenoxyacetamide derivatives

We aimed to discover a novel type of transient receptor potential vanilloid 1 (TRPV1) antagonist because such antagonists are possible drug candidates for treating various disorders. We modified the structure of hit compound 7 (human TRPV1 IC50 = 411 nM) and converted its pyrrolidino group to a (hydroxyethyl)methylamino group, which substantially improved inhibitory activity (15d; human TRPV1 IC50 = 33 nM). In addition, 15d ameliorated bladder overactivity in rats in vivo.

Substituted Heterocyclic Aza Compounds

Heterocyclic aza compounds as vanilloid receptor ligands, pharmaceutical compositions containing these compounds and also methods of using these compounds for the treatment and/or inhibition of pain and further diseases and/or disorders.