259522-64-0

Basic information

• Product Name: 7,10,13-tri(triethylsilyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-deacetylbaccatin III
• Synonyms: 7,10,13-tri(triethylsilyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-deacetylbaccatin III
• CAS NO: 259522-64-0
• Molecular Weight: 921.832
• Mol File: 259522-64-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 7,10,13-tri(triethylsilyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-deacetylbaccatin III(CAS DataBase Reference)
• NIST Chemistry Reference: 7,10,13-tri(triethylsilyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-deacetylbaccatin III(259522-64-0)
• EPA Substance Registry System: 7,10,13-tri(triethylsilyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-deacetylbaccatin III(259522-64-0)

Safety Data

• Hazardous Substances Data: 259522-64-0(Hazardous Substances Data)

Upstream product

• 194720-19-9 7,10,13-tris(triethylsilyl)-10-deacetylbaccatin III 
• 204580-30-3 10-O-deacetyl-2-O-debenzoyl-7,10,13-O-tris(triethylsilyl)baccatin III 
• 535-80-8 3-chlorobenzoate 
• 32981-86-5 10-deacetylbaccatin III 
• 994-30-9 triethylsilyl chloride 

Downstream Products

• 926306-88-9 3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-methoxycarbonyldocetaxel 
• 926306-87-8 3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-dimethylcarbamoyldocetaxel 
• 926306-86-7 3'-dephenyl-3'-(2,2-difluorovinyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-propanoyldocetaxel 
• 926306-85-6 3'-dephenyl-3'-(2,2-difluorovinyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-cyclopropanecarbonyldocetaxel 
• 926306-84-5 3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-acetyl-docetaxel 
• 1007094-40-7 C₃₇H₅₁ClO₁₂Si 
• 1007094-39-4 C₃₈H₅₄ClNO₁₁Si 
• 1007094-38-3 C₃₉H₅₃ClO₁₁Si 
• 259522-70-8 2-debenzoyl-2-(3-chlorobenzoyl)-7-triethylsilyl-10-deacetyl-10-propanoylbaccatin III 

Relevant articles and documents

Synthesis and structure-activity relationships of new second-generation taxoids

A series of second-generation taxoids bearing a substituent on the C-2-benzoyl group and modifications at C-3'/C-10 positions was synthesized. These taxoids exhibited 2-3 orders of magnitude higher potency than that of paclitaxel against drug-resistant human breast cancer cell lines. It is also noteworthy that three taxoids showed almost no difference in activity against drug-resistant and drug-sensitive cell lines, which are categorized as 'advanced second generation taxoids'.

Design, synthesis, and biological evaluation of new-generation taxoids

Novel second-generation taxoids with systematic modifications at the C2, C10, and C3′N positions were synthesized and their structure-activity relationships studied. A number of these taxoids exhibited exceptionally high potency against multidrug-resistan

Synthesis of potent taxoids for tumor-specific delivery using monoclonal antibodies

The targeted delivery of taxoids, in the form of taxane-antibody immunoconjugates, requires the preparation of taxoids containing moieties suitable for their conjugation to monoclonal antibodies. A series of taxoids incorporating a disulfide-containing li