Bioorganic and Medicinal Chemistry Letters p. 3423 - 3428 (1999)
Update date:2022-08-05
Topics:
Ojima, Iwao
Wang, Tao
Miller, Michael L.
Lin, Songnian
Borella, Christopher P.
Geng, Xudong
Pera, Paula
Bernacki, Ralph J.
A series of second-generation taxoids bearing a substituent on the C-2-benzoyl group and modifications at C-3'/C-10 positions was synthesized. These taxoids exhibited 2-3 orders of magnitude higher potency than that of paclitaxel against drug-resistant human breast cancer cell lines. It is also noteworthy that three taxoids showed almost no difference in activity against drug-resistant and drug-sensitive cell lines, which are categorized as 'advanced second generation taxoids'.
View Morepuyang hongda shengdao new material co.,ltd.
Contact:+86-393- 4896278
Address:No.29 East Zhongyuan Road
Hangzhou Ocean Chemical Co., Ltd.
website:http://www.hzoceanchem.com
Contact:+86-571-88025872, 28272092, 28272096
Address:Room 623 ,Building No 1 , COFCO Radius Commercial Center Xiwen Road, Xiacheng District, Hangzhou, Zhejiang Province, China
Binzhou Holly Pharmaceutical Co.,Ltd.
Contact:74517
Address:No.15 Dapu Road,Huangpu District Shanghai,P.R.China
Yancheng Smiling Imp & Exp Co., Ltd.
Contact:+86-515-83173586
Address:Rm1207, BLD#03, Phoenix Plaza, Juheng Road, Yancheng, Jiangsu, P.R. China
Shanghai Sinofluoro Scientific Co., Ltd
Contact:+86-21-64279360
Address:Room 1006,Building 3,#58 East Xinjian Road, Shanghai ,201100,China,
Doi:10.1021/ma0113430
(2002)Doi:10.1246/bcsj.42.2589
(1969)Doi:10.1016/0020-1650(69)80195-9
(1969)Doi:10.1021/acs.organomet.0c00494
(2020)Doi:10.1248/yakushi1947.90.5_644
(1970)Doi:10.1021/ja040093a
(2004)
