Bioorganic and Medicinal Chemistry Letters p. 3423 - 3428 (1999)
Update date:2022-08-05
Topics:
Ojima, Iwao
Wang, Tao
Miller, Michael L.
Lin, Songnian
Borella, Christopher P.
Geng, Xudong
Pera, Paula
Bernacki, Ralph J.
A series of second-generation taxoids bearing a substituent on the C-2-benzoyl group and modifications at C-3'/C-10 positions was synthesized. These taxoids exhibited 2-3 orders of magnitude higher potency than that of paclitaxel against drug-resistant human breast cancer cell lines. It is also noteworthy that three taxoids showed almost no difference in activity against drug-resistant and drug-sensitive cell lines, which are categorized as 'advanced second generation taxoids'.
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