170080-05-4

Basic information

• Product Name: (4S,5S)-4,5-diphenyl-2-oxazolidinone
• Synonyms: (4S,5S)-4,5-diphenyl-2-oxazolidinone
• CAS NO: 170080-05-4
• Molecular Weight: 239.274
• Mol File: 170080-05-4.mol

Chemical Properties

• CAS DataBase Reference: (4S,5S)-4,5-diphenyl-2-oxazolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (4S,5S)-4,5-diphenyl-2-oxazolidinone(170080-05-4)
• EPA Substance Registry System: (4S,5S)-4,5-diphenyl-2-oxazolidinone(170080-05-4)

Safety Data

• Hazardous Substances Data: 170080-05-4(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
(4S,5S)-4,5-diphenyl-2-oxazolidinone is utilized as a catalyst in organic synthesis for its ability to catalyze various asymmetric reactions. This makes it an indispensable tool in the production of pharmaceuticals and other fine chemicals, where the creation of chiral molecules with high selectivity is essential.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (4S,5S)-4,5-diphenyl-2-oxazolidinone is employed as a catalyst for the synthesis of chiral compounds. Its high selectivity in asymmetric reactions is particularly valuable in the development of new drugs and the improvement of existing ones, ensuring the production of the desired enantiomers with precision.
Used in Fine Chemicals Production:
(4S,5S)-4,5-diphenyl-2-oxazolidinone also serves as a catalyst in the production of fine chemicals, where the synthesis of specific chiral molecules is crucial. Its application in this field contributes to the creation of high-quality specialty chemicals with tailored properties for various applications.

Upstream product

• 103-30-0 (E)-1,2-diphenyl-ethene 
• 51-79-6 urethane 
• 100-52-7 benzaldehyde 
• 2325-10-2 (S,S)-hydrobenzoin 
• 1689-71-0 cis-1,2-diphenyloxirane 
• 77789-91-4 (1S,2S,1'S)-2-(1'-phenylethyl)amino-1,2-diphenylethanol 
• 97-72-3 2-Methylpropionic anhydride 
• 19190-95-5 rel-(4R,5R)-4,5-diphenyloxazolidin-2-one 
• 450370-71-5 (4S,5S,1'S)-N-(1'-phenylethyl)-4,5-diphenyl-2-oxazolidinone 
• 259539-62-3 (4S,5S)-3-Benzoyl-4,5-diphenyl-oxazolidin-2-one 

Downstream Products

• 259539-75-8 ((1S,2S)-2-Hydroxy-1,2-diphenyl-ethyl)-carbamic acid tert-butyl ester 
• 530-36-9 (1S,2S)-2-amino-1,2-diphenylethanol 
• 253350-13-9 (4S,5S)-2-Oxo-4,5-diphenyl-oxazolidine-3-carboxylic acid tert-butyl ester 

Relevant articles and documents

Copper-Catalyzed Enantioselective Reductive Cross-Coupling of Aldehydes and Imines

A copper-catalyzed enantioselective reductive cross-coupling using aromatic aldehydes and imines, producing chiral β-amino alcohols, is described. The catalytic formation of enantioenriched chiral α-alkoxyalkylcopper(I) species from aromatic aldehydes and the subsequent reaction with imine electrophiles are attractive features of this protocol.

Kinetic resolution of 2-oxazolidinones via catalytic, enantioselective N-acylation

Kinetic resolution of racemic 2-oxazolidinones via catalytic, enantioselective N-acylation has been achieved for the first time and with outstanding selectivities. Copyright

Chemoselective debezylation of the N-1-phenylethyl group in 2-oxazolidinones by the anisole-methanesulfonic acid system

The chemoselective removal of N-1-phenylethyl group in 2-oxazolidinones by the anisole-methanesulfonic acid system was investigated. Optically active 4,5-cis- and 4,5-trans-diphenyl-2-oxazolidinones (1a-d) were easily synthesized from dl-stilbene oxides (trans- and cis-7a) using this debenzylation.

Practical modifications and applications of the sharpless asymmetric aminohydroxylation in the one-pot preparation of chiral oxazolidin-2-ones

Chiral oxazolidin-2-ones are synthetically valuable as chiral auxiliaries, and many have pharmaceutically interesting biological activity. This communication focuses on a convenient, practical one-pot preparation of chiral 4,5-disubstituted oxazolidan-2-o